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Princess Kate's post-surgery pic ignites even wilder conspiracy theories

<p>In a recent revelation that has the internet buzzing, Kensington Palace released a brand new photo of the Princess of Wales alongside her adorable brood, but it seems like the royal family might be playing with more than just thrones and crowns.</p> <p>The picture, meant to express gratitude to the public for their support during Catherine's recovery from abdominal surgery, quickly became a subject of speculation, leaving royal enthusiasts scratching their heads and raising eyebrows faster than you can say "corgi".</p> <p>The image, which features Catherine sitting and embracing her children – Prince Louis, Prince George and Princess Charlotte – in the scenic backdrop of Windsor, seems like a wholesome Mother's Day tribute at first glance. However, upon closer inspection, the cracks in this picture-perfect façade begin to show.</p> <p>Social media erupted with theories faster than a racehorse at Ascot. Some eagle-eyed observers speculated that the photo might have been the handiwork of artificial intelligence, citing suspiciously green grass and leaves in the dead of winter, a rarity even in England where the weather is as unpredictable as a teenage royal's romantic interests.</p> <p>"AI is that you?" asked one astute commentator on Instagram, voicing the suspicions of many.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/C4U_IqTNaqU/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/C4U_IqTNaqU/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by The Prince and Princess of Wales (@princeandprincessofwales)</a></p> </div> </blockquote> <p>"Ummmmm, this photo looks doctored…" wrote another astute reader. "Catherine’s right hand around Louis is entirely blurry but the left hand around Charlotte, at the same distance to the camera, is not, and either is Louis’ jumper around the hand blurry. Also Charlotte’s dress, which is clothing her torso behind her arm, impedes on the sleeve at the wrist… the cardigan sleeve shows the dress in front of it, when it should only be behind. And Louis’ middle finger must be awfully long to be entirely wrapped around the next finger without being able to see the finger nail… it’s also blurry. I’m a keen photographer, and those are not true elements of a photo as taken."</p> <p>But wait, there's more! The absence of Catherine's wedding ring did not escape the notice of keen observers, prompting questions about the state of her marriage. "WHERE'S YOUR RING??!" demanded one fan, while another pondered, "no ring, tree in full bloom in winter, jeans after major abdominal surgery, face shape completely different from car photo."</p> <p>And if that wasn't enough to fuel the royal gossip mill, Prince Louis's peculiar finger-crossing gesture sent conspiracy theorists into overdrive. Is he sending secret messages? Or is it just further evidence that we're all living in a simulation run by an eccentric royal fan with a knack for Photoshop?</p> <p><span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">Additionally, a subtle misalignment in Princess Charlotte's hand compared to her jumper sleeve raised clear suspicions of digital manipulation. As the speculation grew louder, four of the world's largest photo agencies – The Associated Press, AFP, Getty Images and Reuters – issued a "mandatory kill notice", on the image, effectively retracting it from circulation.</span></p> <p>The reasons cited varied slightly among the agencies, with mentions of "editorial issues" and inconsistencies in the photograph's details. The decision to retract the photo wasn't taken lightly; it's a standard protocol for picture agencies to withdraw images that have been significantly altered.</p> <p>The reaction on social media was swift, with royal watchers and media personalities dissecting the image for clues. Chris Ship, ITV News's royal editor, shared close-up sections of the photo, highlighting apparent discrepancies in Charlotte's sleeve, Prince Louis's jumper, and the background behind him. His commentary underscored the seriousness of the situation, questioning Kensington Palace – the source of the photo – about the authenticity of the image.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">I’ve never been much of a conspiracy theorist but if <a href="https://twitter.com/AP?ref_src=twsrc%5Etfw">@AP</a> <a href="https://twitter.com/AFP?ref_src=twsrc%5Etfw">@AFP</a> <a href="https://twitter.com/Reuters?ref_src=twsrc%5Etfw">@Reuters</a> &amp; other picture agencies are concerned enough to remove it and ask clients to delete it, there are serious questions for Kensington Palace - which was the source of the photo.<br />These appears to be the issues 👇 <a href="https://t.co/ifcSB9mUzu">https://t.co/ifcSB9mUzu</a> <a href="https://t.co/bH5gN9fJtJ">pic.twitter.com/bH5gN9fJtJ</a></p> <p>— Chris Ship (@chrisshipitv) <a href="https://twitter.com/chrisshipitv/status/1766947758529822803?ref_src=twsrc%5Etfw">March 10, 2024</a></p></blockquote> <p>Amidst the fervent speculation, Kensington Palace remained silent, neither confirming nor denying the allegations of photo manipulation. The lack of clarity has only fuelled the fire, leading to further conjecture about the intentions behind the controversial image.</p> <p>In a world where every pixel is scrutinised and every detail dissected, the royal family's attempt at a heartwarming family photo has turned into a comedic saga worthy of a Shakespearean farce.</p> <p>As the internet continues to buzz with speculation, one thing is for certain: when it comes to the royals, truth is often stranger than fiction. Or in this case, more digitally manipulated than reality TV.</p> <p><em>Image: Instagram</em></p>

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Got no COVID-19 symptoms? A gene mutation might be the reason

<div> <div class="copy"> <p>A global study has unearthed a possible genetic reason why some people infected with the virus that causes COVID-19 show no symptoms.</p> <p>Human leukocyte antigens – or HLAs – are important genes that support immune function in the human body, particularly in identifying viral pathogens.</p> <p>And a particular variation in the HLA-B complex has been found to at least double the likelihood that a person infected with SARS-CoV-2 will be asymptomatic.</p> <p>For people who inherit a copy of the HLA-B15 variant from one parent, there was a 2.4 times greater chance of avoiding symptoms. Homozygous carriers — born with copies of the variant from each parent — were 8.5 times more likely to avoid symptoms.</p> <p>It’s a somewhat common variant among certain ethnicities – about 1 in 10 people with European ancestry are potential carriers – but having the gene is not a guaranteed protector against coronavirus symptoms.</p> <p>The findings, <a href="https://doi.org/10.1038/s41586-023-06331-x" target="_blank" rel="noreferrer noopener" data-type="URL" data-id="https://doi.org/10.1038/s41586-023-06331-x">published</a> in <em>Nature</em>, have emerged from a joint study between researchers at the University of California San Fransisco and Australian institutions including Latrobe University, Monash University and the QIMR Berghofer Centre.</p> <p>The research came about almost by accident.</p> <div class="in-content-area content-third content-right"><a href="https://cosmosmagazine.com/health/covid/link-between-blood-type-and-risk-of-covid-19-infection/"> </a></div> <p>Co-lead authors Professor Stephanie Gras from Latrobe and Jill Hollenbach from UCSF first met at a research conference in May 2022 and pooled their resources to track the association of possible gene variations with COVID-19 symptoms.</p> <p>Their teams narrowed a group of 30,000 people with high-quality HLA data to a cohort of about 1,500 unvaccinated people who tested positive for the virus. They then focussed on five locations of interest in the HLA genes while monitoring the emergence of symptoms to determine which variants, if any, might have a greater linkage to being COVID asymptomatic.</p> <p>“The [SARS-CoV-2] virus gets inside cells and ‘presents’ some small part of the virus on the surface via the HLA molecule,” Gras explains.</p> <p>“Those act as a red flag for T cells. The cell sends the signal to the T cell that it has been infected with the virus, and the T cells get activated and kill that [infected] cell.</p> <p>“HLA-B15 can actually present a small part of the spike protein that is very similar between SARS-CoV-2 and seasonal coronaviruses… [that] circulate every year in the population and give us the common cold during winter most of the time. They share some similarities.”</p> <p>The understanding provides a possible application for future treatments. Now an association between the variant and asymptomatic cases has been identified, the Gras and Hollenbach teams have begun to study the interaction between HLA-B15 and the SARS-CoV-2 spike protein at the atomic level.</p> <p>That research is already underway, including at the Australian Synchrotron at the Australian Nuclear Science and Technology Organisation.</p> <p>“We’re doing atomic-level models of proteins to understand the interaction,” Gras says.</p> <p>“We want to compare the T cells within people who are asymptomatic with HLA-B15 and people who are not asymptomatic with HLA-B15. Actually, HLA-B15 is not a magic bullet, you can have it and still have severe COVID.”</p> <p><em>Image credits: Getty Images</em></p> </div> <div id="contributors"> <p><em><a href="https://cosmosmagazine.com/health/covid/got-no-covid-19-symptoms-a-gene-mutation-might-be-the-reason/">This article</a> was originally published on <a href="https://cosmosmagazine.com">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/matthew-agius">Matthew Ward Agius</a>. </em></p> </div> </div>

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“Irwin genes are strong”: Bindi shares adorable candid snap

<p>Bindi Irwin has delighted fans after sharing a sweet snap of her two-year-old daughter, Grace Warrior cuddling a giant tortoise.</p> <p>The wildlife warrior took to Instagram to share the sweet snap with a comparison photo of herself hugging a giant tortoise when she was around Grace’s age.</p> <p>“Holding my newborn daughter wondering if she’ll love wildlife like I did” she captioned one of the photos in the Reel.</p> <p>The next two photos showed comparison photos of the mother-daughter duo which showed that the apple doesn’t fall far from the tree.</p> <p>“Our Grace Warrior, the Wildlife Warrior," she captioned the post.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/reel/Cs4wPGzBjZZ/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/reel/Cs4wPGzBjZZ/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by Bindi Irwin (@bindisueirwin)</a></p> </div> </blockquote> <p>The adorable photo has been praised by fans who commented how proud Steve Irwin would be of his daughter and granddaughter.</p> <p>"It’s in the Irwin blood! You guys have the most beautiful connection with wildlife and each other! Steve Irwin genes are strong!” wrote one fan.</p> <p>"Your dad is probably so so proud looking down,” commented a second person.</p> <p>"This gives me happy goosebumps babe,” wrote a third.</p> <p><em>Images: Instagram</em></p>

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"The wilderness of mirrors": 70 years since the first James Bond book, spy stories are still blurring fact and fiction

<p>"The scent and smoke and sweat of a casino are nauseating at three in the morning."</p> <p>With these opening words, Ian Fleming (1908-64) introduced us to the gritty, glamorous world of James Bond.</p> <p>Fleming’s first novel, <a href="https://www.ianfleming.com/items/casino-royale/">Casino Royale</a>, was published 70 years ago on April 13 1953. It sold out within weeks. British readers, still living with rationing and shortages after the war, eagerly devoured the first James Bond story. It had expensive liquor and cars, exotic destinations, and high-stakes gambling – luxurious things beyond the reach of most people.</p> <p>The novel’s principal villain is Le Chiffre, the paymaster of a French trade union controlled by the Soviet intelligence agency SMERSH. After losing Soviet money, Le Chiffre takes to high-stakes gambling tables to recover it. Bond’s mission is to play against Le Chiffre and win, bankrupting both the Frenchman and the union. </p> <p>The director of British intelligence, known only by his codename “M”, also assigns Bond a companion – Vesper Lynd, previously one of the agency’s assistants. The two infiltrate the casino, play at the tables, and dodge assassination attempts, while engaging in a dramatic battle with French communists, the Soviets, and each other.</p> <p>Fleming’s Bond – the sophisticated, tuxedo-clad secret agent – is an enduring image of espionage. Since 1953, martinis, gadgets, and a licence to kill have been part of how ordinary people understand spycraft. </p> <p>Some of this was real: Fleming drew on his own work as a spy for his novels. Intelligence work is often less glamorous than he depicted, but in both espionage and novel-writing, the difference between fact and fiction is not always easy to distinguish. </p> <h2>Ian Fleming, Agent 17F</h2> <p>Fleming came from a wealthy, well-connected British family, but he was a mediocre student. He only lasted a year at military college (where he contracted gonorrhoea), then missed out on a job with the Foreign Office. He could write, though. He spent a few years as a journalist, but drifted purposelessly through much of the 1930s. </p> <p>The outbreak of war in 1939 changed everything. The director of British Naval Intelligence, Admiral John Henry Godfrey, recruited Fleming as his assistant. Fleming excelled, under the codename 17F. He didn’t see much of the war firsthand, but was involved in its planning. He was an ideas man, not overly concerned with practicalities or logistics. Fleming came up with the fictions; other people had to turn them into realities. </p> <p>In 1940, for example, he developed “<a href="https://www.reuters.com/article/entertainment-britain-fleming-bond-finea-idCAL1663266620080416">Operation Ruthless</a>”. To crack the German naval codes, Fleming planned to lure a German rescue boat into a trap and steal its coding machine. They would obtain a German bomber, dress British men in German uniforms, and deliberately crash the plane into the channel. When the German rescue crew arrived, they would shoot them and grab the machine. </p> <p>Preparations began but Fleming’s plan never eventuated. It was too difficult and risky – not least because crashing the plane might simply kill their whole crew.</p> <p>Fleming worked on various operations. When he began writing after the war, these experiences found their way into Bond’s world. Fleming and Godfrey had visited Portugal, a neutral territory teeming with spies, where they went to the casino. Fleming claimed he played against a German agent at the tables, an experience that supposedly inspired Bond’s gambling battles with Le Chiffre in Casino Royale. </p> <p>Godfrey maintained that Fleming only ever played against Portuguese businessmen, but Fleming never let facts get in the way of a good story.</p> <p>Fleming picked up inspiration everywhere. Godfrey became the model for M. Fleming’s secretary, Joan Howe, inspired Moneypenny. The Soviet SMERSH coding device in <a href="https://jamesbond.fandom.com/wiki/From_Russia_with_Love_(novel)">From Russia, With Love</a> (1957) was based on the German Enigma machine. Many of Fleming’s characters were named for real people: one villain shares a name with Hitler’s Chief of Staff, another with one of Fleming’s schoolyard adversaries.</p> <p>It became something of a sport to hypothesise about the inspiration for Bond. Fleming later called him a “compound of all the secret agents and commando types” he met during war. There were elements of Fleming’s older brother, an operative behind the lines in Norway and Greece. Fleming also pointed to <a href="https://en.wikipedia.org/wiki/Sidney_Reilly">Sidney Reilly</a>, a Russian-born British agent during the First World War. He had access to reports on Reilly in the Naval Intelligence archive during his own service. </p> <p>Other possible models include <a href="https://en.wikipedia.org/wiki/Conrad_O%27Brien-ffrench">Conrad O’Brien-ffrench</a>, a British spy Fleming met while skiing in the 1930s, and <a href="https://en.wikipedia.org/wiki/Wilfred_Dunderdale">Wilfred “Biffy” Dunderdale</a>, MI6 Station Chief in Paris, who wore handmade suits and was chauffeured in a Rolls Royce. Stories of discovering <a href="https://www.smh.com.au/lifestyle/mr-bond-i-presume-20141017-117xji.html">the real-life James Bond</a> still appear.</p> <p>But there was also much of Fleming himself in Bond. He gave 007 his own love of scrambled eggs and gambling. Their attitude towards women was similar. They used the same brand of toiletries. Bond even has Fleming’s golf handicap. </p> <p>Fleming would play with this idea, teasing that the books were autobiographical or that he was Bond’s biographer. Much like a cover story for an intelligence officer, Bond was Fleming’s alter-ego. He was anchored in Fleming’s realities – with a strong dash of creative licence and a little aspiration.</p> <h2>The changing world of Bond</h2> <p>The success of Casino Royale secured contracts for more Bond novels. In the early 1960s, critics began to denounce the books for their “sex, snobbery, and sadism”. Bond’s attitude toward women, in particular, was clear from the beginning. In Casino Royale, he refers to the “sweet tang of rape” in relation to sex with his MI6 accomplice and paramour Vesper Lynd. </p> <p>But the public appeared to be less concerned. Bond novels still sold well, especially after John F. Kennedy listed one among his top ten books. The first film adaptation, <a href="https://www.imdb.com/title/tt0055928/">Dr. No</a>, appeared in 1962 and Fleming’s success continued apace.</p> <p>Bond’s world was evolving, though. From Casino Royale to For Your Eyes Only (1960), Bond battled SMERSH, a real Soviet counter-espionage organisation. The early Bond novels were Cold War stories. Soviet Russia was the West’s enemy, so it was Bond’s. </p> <p>But East-West relations were thawing in 1959 when Fleming was writing Thunderball (1961). The Cold War could plausibly have ended and he didn’t want any film version to look dated, so Fleming created a fictional villain: SPECTRE. This was an international terrorist organisation without a distinct ideology. It could endure beyond the battles of the Cold War – and did. It features in the 2021 Bond film <a href="https://www.imdb.com/title/tt2382320/">No Time To Die</a>.</p> <p>Fleming’s more fantastic plots were always anchored in reality by recognisable brands and products. Bond’s watch was a Rolex; his choice of bourbon was Jack Daniels. His cigarettes were Morlands, like Fleming’s. In the novels, Bond drove Bentleys – the Aston Martin was introduced in the 1964 film <a href="https://www.imdb.com/title/tt0058150/">Goldfinger</a>. </p> <p>The films have changed Bond’s brands to keep up with the world around them (and secure lucrative product-placement deals): Omega replaced Rolex in <a href="https://www.imdb.com/title/tt0113189/">Goldeneye</a> (1995); the <a href="https://www.theguardian.com/film/2012/apr/17/bond-taste-for-beer-skyfall">martini was swapped for a Heineken</a> in <a href="https://www.imdb.com/title/tt1074638/">Skyfall</a> (2012). Bond now carries a Sony phone.</p> <p>Other changes brought the 1950s spy into the 21st century. Recent films have more diverse casting. Their female characters do more than just spend a night with Bond before their untimely deaths. The novels, too, continue to change – the 70th-anniversary editions have had <a href="https://www.theguardian.com/books/2023/feb/27/james-bond-novels-to-be-reissued-with-racial-references-removed">racial slurs and some characters’ ethnic descriptors removed</a>. </p> <p>Some have criticised this as censorship. But as with <a href="https://theconversation.com/roald-dahl-a-brief-history-of-sensitivity-edits-to-childrens-literature-200500">recent rewritings of Roald Dahl’s books</a>, changes like this are not new. Fleming’s family has <a href="https://www.abc.net.au/news/2023-02-28/ian-fleming-james-bond-books-changes-to-new-editions/102035958">defended the alterations by citing similar removals</a> in 1955, when Live and Let Die was first published in the United States. </p> <p>There is a risk that this whitewashes Fleming’s attitudes, making them appear more palatable than they really were. But the revised Bond novels will include a disclaimer noting the removals. Casino Royale itself has not been altered (Bond’s rape comment remains intact), so the changes will perhaps be less extensive than the media coverage suggests.</p> <h2>Spies After Bond</h2> <p>Fleming is not the only ex-spy to have successfully turned his hand to spy fiction. John le Carré’s George Smiley is perhaps an anti-Bond: slightly overweight, banal, and essentially a bureaucrat. He relies on a shrewd mind rather than gadgets or guns. </p> <p>Le Carré introduced his readers to a more mundane, morally grey world of espionage. He had worked for MI5 and MI6 in the 1950 and ‘60s. He thought Bond was a gangster rather than a spy. Le Carré’s stories have also shaped how we think about espionage. Words like “mole” and “honeytrap” – the terminology of spycraft – <a href="https://www.theatlantic.com/books/archive/2023/02/john-le-carre-spy-came-in-from-cold-book/673227/">entered common usage via his novels</a>.</p> <p>Stella Rimington, <a href="https://www.theguardian.com/lifeandstyle/2022/apr/23/stella-rimington-i-fell-into-intelligence-by-chance">the first female director-general of MI5</a>, began writing fiction after retiring from intelligence in the late 1990s. Her protagonist, 34-year-old Liz Carlyle, hunts terror cells in Britain. Like Smiley, Carlyle appears rather ordinary. She is serious and conscientious. We get glimpses of the everyday sexism she experiences. Carlyle triumphs by remaining level-headed, not by fiery gun battles or explosions.</p> <p>After three decades of agent-running for the CIA, Jason Mathews wrote his <a href="https://www.simonandschuster.com/series/The-Red-Sparrow-Trilogy">Red Sparrow</a> trilogy to occupy himself in retirement. He called it <a href="https://www.nytimes.com/2015/05/28/books/shadowing-jason-matthews-the-ex-spy-whose-cover-identity-is-author.html">a form of therapy</a>. </p> <p>There’s a little more Bond in Mathews’ books than in those of le Carré or Rimington. His protagonists Nate Nash and Dominika Egorova are attractive, charismatic and entangled in a personal relationship of stolen moments and high drama. This is counterbalanced by the many hours they spend running surveillance-detection routes before meeting targets. The more tedious and banal aspects of spycraft – brush passes, broken transmitters, and dead drops – accompany the glamour and romance.</p> <h2>The wilderness of mirrors</h2> <p>Spy fiction is never just about entertainment. The real world of espionage is so secret that most of us only ever encounter it on pages or screens. We don’t usually look to Bond films for accurate representations of espionage. But the influence of Fleming’s spy and the general aura of secrecy surrounding intelligence work lend some glamour and excitement to the work of real spies.</p> <p>These fictions also influence our views on real intelligence organisations, their activities, and their legitimacy. This is why the <a href="https://lareviewofbooks.org/article/the-cia-goes-to-hollywood-how-americas-spy-agency-infiltrated-the-big-screen-and-our-minds/">CIA invests time and money into fictionalisations</a> dealing with its work. From stories based on true events, such as <a href="https://www.imdb.com/title/tt1024648/">Argo</a>(2012) or <a href="https://www.imdb.com/title/tt1790885/">Zero Dark Thirty</a> (2012), to fictional series like <a href="https://www.imdb.com/title/tt1796960/">Homeland</a> (2011-20), the agency’s image is shaped via the media we consume.</p> <p>This was true when Fleming was writing, too. Soviet authorities <a href="https://www.routledge.com/Russia-and-the-Cult-of-State-Security-The-Chekist-Tradition-From-Lenin/Fedor/p/book/9780415703475">were preoccupied</a> by Sherlock Holmes’ surging popularity behind the Iron Curtain and fretted over the release of the Bond novels and films. The KGB studied both carefully. It was likely Bond who prompted KGB officers to release classified details about their most successful spy story: the career of <a href="https://www.spectator.co.uk/article/the-name-s-sorge-richard-sorge/">Richard Sorge</a>. </p> <p>Former intelligence officers such as Fleming are often quite good at fiction – perhaps because it is a core part of spycraft. A solid cover story has to be grounded in reality, with just enough fiction to protect the truth or gain a desired outcome. A good operation often requires creativity, to outwit a target or evade detection. And spreading fictions – disinformation – can sometimes be just as useful as gathering information.</p> <p>The world of espionage is sometimes referred to as the “wilderness of mirrors”. Spycraft relies on both reflections and distortions. The line between fact and fiction, between real stories of intelligence work and invented ones, can become blurry – and intelligence agencies often prefer it that way.</p> <p><em>Image credits: Columbia Pictures</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/the-wilderness-of-mirrors-70-years-since-the-first-james-bond-book-spy-stories-are-still-blurring-fact-and-fiction-201373" target="_blank" rel="noopener">The Conversation</a>. </em></p>

Books

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KISS concert halted as Gene Simmons falls ill on stage

<p>KISS singer Gene Simmons gave fans - and bandmates - a fright when dehydration got the better of him live on stage, and the group were forced to bring their entire concert to a halt. </p> <p>In a video from the event, KISS’ Paul Stanley can be seen addressing the crowd, telling them that “we’re gonna have to stop to take care of him. Because we love him, right?”</p> <p>He goes on to call for a cheer for Simmons, with the 73-year-old catching his breath on a chair on stage - the same chair that he remained in for the rest of the show, after a five minute break to assure he was well enough to continue.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="pt">Gene Simmons, baixista e vocalista do Kiss, passa mal e show é brevemente interrompido na Arena da Amazônia. <a href="https://t.co/nphJEj1PQo">pic.twitter.com/nphJEj1PQo</a></p> <p>— A Crítica (@ACritica) <a href="https://twitter.com/ACritica/status/1646372105523478529?ref_src=twsrc%5Etfw">April 13, 2023</a></p></blockquote> <p>And while fans were concerned for the singer, he later took to social media to assure them that he was “fine” and looking forward to the band’s next stadium performance. </p> <p>“I’m fine. Yesterday at Manaus Stadium in Brazil, [I] experienced weakness because of dehydration,” he explained. “We stopped for about five minutes, I drank some water, and then all was well. Nothing serious.”</p> <p>“Brazil is hotter than hell!!” one fan responded, “so glad you're okay and I can't wait to see you in São Paulo! Take care, god of thunder!!”</p> <p>“Even the God of Thunder needs hydration,” another agreed. “Good to hear you're doing well.”</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Hey everybody, thanks for the good wishes. I’m fine. Yesterday at Manaus Stadium in Brazil, experienced weakness because of dehydration. We stopped for about five minutes, I drank some water, and then all was well. Nothing serious. Tomorrow, Bogota Stadium. See you there!</p> <p>— Gene Simmons (@genesimmons) <a href="https://twitter.com/genesimmons/status/1646530305791266818?ref_src=twsrc%5Etfw">April 13, 2023</a></p></blockquote> <p>And as news broke around the world of what had gone down in Brazil, Simmons returned with another round of assurances, writing that it was “not a big deal” while again thanking everyone for their well wishes. </p> <p>“Last night we played Amazon jungle Stadium/Brazil. Humidity and temperature were sky high. I was dehydrated and was forced to sit for a song,” he said. “We got back on stage in 5 minutes &amp; finished the show.”</p> <p>It was enough for his fans, who were quick to share their delight that their star was okay, as well as voicing their excitement for upcoming shows - with a good portion of requests for the singer to take care of himself, and avoid a repeat performance. </p> <p>“Happy to hear you're doing better,” one wrote. “Even more happy it wasn’t anything serious.Ya'll take care.”</p> <p>“Frankly, I don’t know [how] you do it every night. You’re amazing!” another declared. </p> <p>Meanwhile, some could see the humour in it all now that their fears had been put to rest, with one joking “and who says playing music couldn't be dangerous”.</p> <p><em>Images: Twitter</em></p>

Caring

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Super rare pic of unrecognisable Gene Hackman

<p>For the first time in a long time, legendary actor Gene Hackman has been spotted out and about at the age of 93.</p> <p>The icon had been reclusive in recent years, and these are the first photos of him snapped in a very long time. </p> <p>The <em>Superman</em> star still seemed fit and looked quite healthy in the snaps taken in Santa Fe, New Mexico. </p> <p>The retired actor was spotted enjoying a fast food lunch at a parking lot after going through the Wendy’s drive-thru. </p> <p>He is still sporting his signature moustache in the rare sighting. </p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">New photos of Hollywood Legend Gene Hackman have been released. He is currently 93-years-old. These are the first photos of him in years. <a href="https://t.co/5pn1wXN81w">pic.twitter.com/5pn1wXN81w</a></p> <p>— Daily Loud (@DailyLoud) <a href="https://twitter.com/DailyLoud/status/1633270131324223489?ref_src=twsrc%5Etfw">March 8, 2023</a></p></blockquote> <p>Hackman’s last movie role was with Ray Romano and Christine Baranski in the 2004 comedy <em>Welcome To Mooseport</em>. </p> <p>In July 2004, Hackman was interviewed by Larry King, where he announced there were no new film projects lined-up and believed his acting career was over.</p> <p>Years later, the star confirmed his retirement while promoting his third novel <em>Escape From Andersonville</em>, back in 2008.</p> <p>In an interview with CQ in 2011, he was asked if he would ever come out of retirement to do another film, and he responded, “If I could do it in my own house, maybe, without them disturbing anything and just one or two people.”</p> <p>CQ also asked him, “how do you want to be remembered?"</p> <p>“As someone who tried to portray what was given to them in an honest fashion. I don't know, beyond that. I don't think about that often, to be honest. I'm at an age where I should think about it.” He said with a laugh.</p> <p>Hackman has long been one of the most highly regarded film actors of all time, leading his Mississippi Burning director Alan Parker to state that “he is incapable of bad work. Every director has a shortlist of actors he’d die to work with, and I’ll bet Gene’s on every one.”</p> <p>The thespian really made waves when he was nominated for an Oscar for the Best Supporting Actor category for the 1970s film<em> I Never Sang For My Father</em>.</p> <p>A year later, he became a leading man in incredible fashion, winning the Academy Award for Best Actor in his New York City Detective Jimmy 'Popeye' Doyle in <em>The French Connection</em> (1971). </p> <p>Hackman’s career only went up from there, with countless awards under his belt, including two Oscars, two BAFTA awards and two Golden Globes.</p> <p><em>Image credit: Getty</em></p>

Movies

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Severe COVID-19 linked to signs of ageing in the brain

<p dir="ltr">COVID-19 infection has been associated with the same molecular changes seen in ageing brains, including higher levels of activity from genes associated with the ageing process.</p> <p dir="ltr">As we age, our brains shrink - with a five percent decline in weight per decade after the age of 40 - while our memory and levels of neurotransmitters like serotonin and dopamine decline.</p> <p dir="ltr">With previous research finding that people who are infected with Covid can experience neurological conditions after they recover, as well as declines in cognitive performance that mimic accelerated ageing, a team of researchers from Harvard Medical School examined the brain tissue of 54 deceased people, including 21 who had severe Covid infections.</p> <p dir="ltr">They found that changes in how genes were expressed in the brains of Covid-infected people were similar to what is seen in older brains.</p> <p dir="ltr">Using a particular kind of analysis called whole-transcriptome sequencing, the team were able to investigate which genes were being switched on and off in a person at the time of their death, comparing brain samples from people infected with Covid and those who hadn’t been infected (from before the pandemic).</p> <p dir="ltr">In comparison to the uninfected group, the Covid group showed higher levels of activity for genes associated with immunity. Meanwhile, genes linked to cognition, memory and the activity of synapses, which are essential for helping impulses travel through the nervous system, had lower levels of expression.</p> <p dir="ltr">"We also observed significant associations of cellular response to DNA damage, mitochondrial function, regulation of response to stress and oxidative stress, vesicular transport, calcium homeostasis, and insulin signalling/secretion pathways previously associated with ageing processes and brain ageing," they wrote.</p> <p dir="ltr">"Altogether, our analyses suggest that many biological pathways that change with natural ageing in the brain also change in severe COVID-19."</p> <p dir="ltr">Also investigating the trigger of these changes, they found increased levels of activity in several inflammatory pathways associated with ageing in the brain, and that specific immune cells influence the expression of several of these genes.</p> <p dir="ltr">This supports the hypothesis that the neurological symptoms that can accompany Covid are caused by inflammation triggered by the virus.</p> <p dir="ltr">But they also explored the other hypothesis, that the neurological symptoms are caused by the virus infiltrating and infecting the brain - specifically the frontal cortex - by looking to see whether there was evidence of Covid RNA (which contains the virus’ genetic material it needs to replicate).</p> <p dir="ltr">“In agreement with previous studies, SARS-CoV-2 viral RNA was not detected in samples from individuals with COVID-19, suggesting that the observed gene expression changes are unlikely due to the effects of the viral RNA in the frontal cortex,” they wrote.</p> <p dir="ltr">With these findings, the researchers concluded that managing Covid-induced inflammation could protect against the development of the neurological symptoms associated with Covid.</p> <p dir="ltr">They also argue that following up with patients recovering from Covid could be beneficial in reducing the risk or delaying the neurological symptoms and cognitive decline.</p> <p dir="ltr">Speaking to <em>Nature</em>, neuropathologist Marianna Bugiani, who wasn’t involved in the study, said that it’s still difficult to know whether these changes to gene expression are permanent or whether they are also seen in people experiencing mild bouts of Covid.</p> <p dir="ltr">“It opens a plethora of questions that are important, not only for understanding the disease, but to prepare society for what the consequences of the pandemic might be,” she said.</p> <p><span id="docs-internal-guid-df4fb67d-7fff-854d-6942-559608bd9c1f">“And these consequences might not be clear for years.”<br /></span></p> <p>The researchers published their findings in the journal <a href="https://doi.org/10.1038/s43587-022-00321-w" target="_blank" rel="noopener"><em>Nature Aging</em></a>.</p> <p><em>Image: Getty Images</em></p>

Mind

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Chris Hemsworth’s Alzheimer’s gene doesn’t guarantee he’ll develop dementia

<p>Chris Hemsworth, famous for his role as the god Thor in Marvel Cinematic Universe movies, has announced he will be <a href="https://www.theguardian.com/film/2022/nov/21/chris-hemsworth-to-take-time-off-from-acting-after-discovering-alzheimers-risk" target="_blank" rel="noopener">taking a break</a> from acting after being told he has two copies of the <a href="https://www.nia.nih.gov/news/study-reveals-how-apoe4-gene-may-increase-risk-dementia" target="_blank" rel="noopener">APOE4 gene</a>, increasing his risk of Alzheimer’s.</p> <p>Having one copy of the <a href="https://www.science.org/doi/abs/10.1126/science.8346443" target="_blank" rel="noopener">APOE4 gene</a> increases your risk for Alzheimer’s 2-3 times. Two copies increases your risk 10-15 times.</p> <p>But the key here is “risk”. Having one or more copies of the gene doesn’t guarantee Chris or anyone else in a similar situation will go on to develop Alzheimer’s, the most common form of dementia.</p> <p><strong>Sharing the news</strong></p> <p>Hemsworth’s willingness to share his concerns about developing Alzheimer’s with millions should be applauded. It’s a reminder to all of us to keep an eye on our health and reduce our risk of future illness.</p> <p>Alzheimer’s, and dementia more broadly, is <a href="https://www.dementiastatistics.org/statistics/global-prevalence/" target="_blank" rel="noopener">set to challenge</a> health-care systems worldwide.</p> <p>In Australia alone there are <a href="https://www.dementia.org.au/statistics" target="_blank" rel="noopener">up to</a> 500,000 people with dementia, supported by almost 1.6 million carers. By 2036, about <a href="https://www.dementia.org.au/sites/default/files/NATIONAL/documents/The-economic-cost-of-dementia-in-Australia-2016-to-2056.pdf" target="_blank" rel="noopener">450 people</a> are predicted to be diagnosed daily. So understanding how APOE4 alters the risk for the major cause of dementia may be pivotal in preventing cases.</p> <p>But not all people with the APOE4 gene go on to develop Alzheimer’s. This means that there may be a combination of environmental factors interplaying with the gene that lead some people to develop Alzheimer’s, while others do not.</p> <p><strong>What’s APOE4 got to do with Alzheimer’s?</strong></p> <p>Most Australians have APOE3 or APOE2 genes. In Caucasians it’s only <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531868/" target="_blank" rel="noopener">about 15%</a>, like Hemsworth, who have inherited an APOE4 gene.</p> <p>The APOE gene types are best known for their role in modulating the metabolism of lipids (fats), such as cholesterol and triglycerides.</p> <p>They code for synthesis of different versions of the protein APOE, with subtle differences in structure. The APOE proteins become an integral part of lipoproteins in the blood. These are the fat-carrying particles your GP measures to consider your risk of heart disease.</p> <p>APOE proteins have a similar function in the brain, to modulate lipid levels. But in the context of Alzheimer’s, researchers study it for its effect on the integrity of brain cells.</p> <p>Accumulating evidence <a href="https://www.sciencedirect.com/science/article/pii/S0197458022000550" target="_blank" rel="noopener">suggests</a> APOE4, is associated with brain inflammation and cellular damage.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">APOE4 is the strongest genetic risk factor for Alzheimer’s disease. A study in <a href="https://twitter.com/Nature?ref_src=twsrc%5Etfw">@Nature</a> establishes a functional link between APOE4, cholesterol, myelination and memory, offering therapeutic opportunities for Alzheimer’s disease. <a href="https://t.co/bNsmDVPfFW">https://t.co/bNsmDVPfFW</a> <a href="https://t.co/58odE1JASl">pic.twitter.com/58odE1JASl</a></p> <p>— Nature Portfolio (@NaturePortfolio) <a href="https://twitter.com/NaturePortfolio/status/1594762841487249410?ref_src=twsrc%5Etfw">November 21, 2022</a></p></blockquote> <p><strong>Can we prevent Alzheimer’s?</strong></p> <p><strong>1. Look after your capillaries</strong></p> <p>Damaged and leaky blood vessels (capillaries) in the brain lead to inflammation, the death of brain cells and cognitive impairment. In fact, in Alzheimer’s, damaged capillaries are the earliest sign of the type of brain damage that causes disease.</p> <p>The protein encoded by the APOE4 gene may be less able to support healthy capillaries in the brain. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0163782709000563" target="_blank" rel="noopener">We suggested</a> APOE4 increases the abundance of specific complexes of lipoproteins and proteins in blood that silently damage brain capillaries, causing them to leak.</p> <p>We also see more brain capillary leakage in mice fed Western-style diets richer in saturated fats.</p> <p>The relationship between how the APOE proteins mediate lipid metabolism and capillary health in humans is poorly understood.</p> <p>But we have 60 years of research knowledge to say with confidence that eating foods good for the heart should also be good for the brain. This is particularly relevant for people with the APOE4 gene.</p> <p>So if you have the APOE4 gene and want to minimise your risk of Alzheimer’s, a healthy diet is a good place to start.</p> <figure class="align-center zoomable"><em><a href="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=3 2262w" alt="Capillaries" /></a></em><figcaption><em><span class="caption">Looking after your capillaries with a healthy diet is a good place to start.</span> <span class="attribution"><a class="source" href="https://www.shutterstock.com/image-illustration/system-many-small-capillaries-branch-out-1745173364" target="_blank" rel="noopener">Shutterstock</a></span></em></figcaption></figure> <p><strong>2. Give your brain a break</strong></p> <p>Reducing unnecessary stimuli to “give your brain a rest” may have big impact over decades of your life. The latter may be a more important consideration if you have the APOE4 gene.</p> <p>That’s because the APOE gene is also linked to how the brain uses energy, which may lead to more <a href="https://www.frontiersin.org/articles/10.3389/fnmol.2018.00216/full" target="_blank" rel="noopener">oxidative stress and damage</a>.</p> <p>While we’ve yet to collect robust data in humans, take a digital detox now and again, plan some down time, and avoid unnecessary stress if you can.</p> <p><strong>Should we test for the APOE4 gene?</strong></p> <p>Some people might be tempted to get tested for the APOE4 gene, especially if there’s a family history of Alzheimer’s.</p> <p>But unless genetic testing is going to change your treatment (for instance, by taking certain medications to slow progression of brain damage), or your behaviour to minimise your risk Alzheimer’s, then testing is not justified.</p> <p>We can’t change the genes our parents gifted us, but we can change our environment.</p> <p>Poor diet, every drop of alcohol you drink, obesity and diabetes, high blood pressure and sedentary behaviour <a href="https://www.dementia.org.au/risk-reduction" target="_blank" rel="noopener">all contribute, over time</a>, to poorer vascular health and increase your risk of dementia.</p> <p>We’re still learning about how these risk factors for Alzheimer’s interact with the APOE4 gene. But there is no reason we shouldn’t all take greater responsibility for minimising our risk of dementia now, whether we have the APOE4 gene or not.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/195094/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em>Writen by John Mamo. Republished with permission from <a href="https://theconversation.com/chris-hemsworths-alzheimers-gene-doesnt-guarantee-hell-develop-dementia-heres-what-we-can-all-do-to-reduce-our-risk-195094" target="_blank" rel="noopener">The Conversation</a>.</em></p> <p><em>Image: Instagram</em></p>

Mind

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This new tech could spell end for mouse plagues

<p dir="ltr">Invasive mice populations could be a thing of the past, thanks to a new genetic tool developed by a team of Australian scientists.</p> <p dir="ltr">Researchers at the University of Adelaide have developed t-CRISPR, which uses gene editing technology to alter the fertility gene in laboratory mice to make females infertile.</p> <p dir="ltr">“This is the first time that a new genetic tool has been identified to suppress invasive mouse populations by inducing female infertility,” said lead researcher Professor Paul Thomas.</p> <p dir="ltr">“The t-CRISPR approach uses cutting-edge DNA editing technology to make alterations to a female fertility gene. Once the population is saturated with the genetic modification, all the females that are generated will be infertile.</p> <p dir="ltr">“We are also developing new versions of t-CRISPR technology that are designed to target specific pest populations to prevent unwanted spread of the gene drive.”</p> <p dir="ltr">The new tool is based on an existing technology, CRISPR-Cas9 gene editing, which has largely been applied to limiting the spread of malaria by making male mosquitoes infertile.</p> <p dir="ltr"><strong>CRISPR 101</strong></p> <p dir="ltr">Since it was unveiled in 2012, the CRISPR method has been used to edit pieces of DNA inside the cells of organisms, primarily insects.</p> <p dir="ltr">“Up until now, this technology has been aimed at insects to try and limit the spread of malaria, which causes up to 500,000 deaths worldwide per year,” Luke Gierus, a post-graduate student and the paper’s co-first author, said.</p> <p dir="ltr">The technology relies on the Cas9 protein found in bacteria, which scientists can program to find and bind to almost any 20-letter sequence of DNA in a gene with the help of a piece of RNA that matches the target DNA sequence.</p> <p dir="ltr">When it finds the target, standard CRISPR cuts the DNA, and the process of repairing the DNA introduces mutations that can disable the gene.</p> <p dir="ltr">Other variations of CRISPR can also replace faulty genes, turn genes on or off, or change one letter of the DNA code to another.</p> <p dir="ltr">In this study, the team simulated what would happen when an edited version of a fertility gene on chromosome 17, which affects the ability of sperm to swim, was introduced to populations of mice. </p> <p dir="ltr">Males who carry one copy of this gene are infertile, while females are still fertile but only have one functioning version of the gene and can pass on either the functioning or non-functioning version to their offspring.</p> <p dir="ltr">In females that had a second edited chromosome that affected their fertility, they found that male offspring would all be infertile, while only 50 percent of female offspring would be fertile.</p> <p dir="ltr">They found that 250 mice with modified genes could eradicate a population of 200,000 mice on an island in around 20 years.</p> <p dir="ltr">“The use of t-CRISPR technology provides a humane approach to controlling invasive mice without the release of toxins into the environment. We are also working on strategies to prevent failed eradication due to the emergence of gene drive resistance in the target population,” Gierus said.</p> <p dir="ltr">While t-CRISPR has been developed to specifically target mice, CSIRO Group Leader for Environmental Mitigation and Resilience Dr Owain Edwards said it could be developed to use on other invasive animals.</p> <p dir="ltr">The researchers, who collaborated with CSIRO, the Centre for Invasive Species Solutions, the Genetic Biocontrol for Invasive Rodents (GBIRd) consortium and the US Department of Agriculture, were supported by both the South Australian and NSW governments.</p> <p dir="ltr">“These promising findings demonstrate how gene drive technology may be a game changer in managing the impacts of mice on our environment, community, and agricultural sector,” South Australian Deputy Premier Dr Susan Close said.</p> <p dir="ltr">“This cutting-edge research also highlights the global leadership of the South Australian research sector, in finding solutions to social, environmental and economic challenges.</p> <p dir="ltr">“The South Australian Government is proud to have supported this proof-of-concept, having granted the University of Adelaide $1 million through the Research and Innovation Fund.”</p> <p dir="ltr">They published their findings in the journal <em><a href="https://doi.org/10.1073/pnas.2213308119" target="_blank" rel="noopener">Proceedings of the National Academy of Sciences</a></em>.</p> <p><span id="docs-internal-guid-bca82366-7fff-dcca-05a4-83502245beac"></span></p> <p dir="ltr"><em>Image: ABC News</em></p>

Family & Pets

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Excelling as a musician takes practice and requires opportunities – not just lucky genes

<p>What makes talented musicians so good at what they do?</p> <p>There’s plenty of evidence that people can be born that way. Research findings suggest that about <a href="https://doi.org/10.1136/jmg.2007.056366">half of musical ability is inherited</a>. Even if that’s true, it doesn’t mean you must have musical talent in your genes to excel on the bass, oboe or drums. </p> <p>And even if you’re fortunate enough to belong to a family that includes musicians, you would still need to study, practice and get expert guidance to play well. </p> <p>As a <a href="https://scholar.google.com/citations?user=34DZlUIAAAAJ&amp;hl=en&amp;oi=ao">music professor and conductor</a>, I’ve seen the role that practice and experience play in propelling musicians toward mastery and success. There are some factors that help a musician get started – and heredity could be one of them. But musical skill is ultimately a complex interplay between <a href="https://doi.org/10.1177%2F0022429416680096">lots of practice and high-quality instruction</a>.</p> <h2>The role genes can play</h2> <p>Of course many great musicians, including some who are world famous, are related to other musical stars.</p> <p>Liza Minnelli, the famed actress, singer and dancer, is one of the late entertainer <a href="https://hollywoodlife.com/feature/judy-garland-kids-4728886/">Judy Garland’s three children</a>. <a href="https://people.com/music/jon-batiste-everything-to-know">Jon Batiste</a> – “The Late Show” bandleader, pianist and composer who has won Emmy, Oscar and Golden Globe awards – has at least 25 musicians in his family. Saxophonist Branford, trumpeter Wynton, trombonist Delfeayo and drummer Jason Marsalis are the <a href="https://www.npr.org/sections/coronavirus-live-updates/2020/04/02/825717204/ellis-marsalis-patriarch-of-new-orleans-most-famous-musical-family-has-died">sons of pianist Ellis Marsalis</a>.</p> <p>Singer and pianist <a href="https://www.notablebiographies.com/news/Ge-La/Jones-Norah.html">Norah Jones</a> is the daughter of Indian sitar player <a href="https://www.vogue.in/culture-and-living/content/norah-jones-on-her-relationship-with-pandit-ravi-shankar-september-2020-cover-interview-hope">Ravi Shankar</a>, though Jones had little contact with her renowned father while growing up.</p> <p>Absolute pitch, also known as perfect pitch, is the ability to recognize and name any note you hear anywhere. Researchers have found that it <a href="https://doi.org/10.1086/301704">may be hereditary</a>. But do you need it to be a great musician? Not really.</p> <h2>Most people are born with some musical ability</h2> <p>I define musical ability as the possession of talent or potential – the means to achieve something musical.</p> <p>Then there’s skill, which I define as what you attain by working at it.</p> <p>You need at least some basic musical ability to acquire musical skills. Unless you can hear and discern pitches and rhythms, you can’t reproduce them.</p> <p>But people may overestimate the role of genetics because, with very rare exceptions, <a href="https://www.apa.org/monitor/feb05/absolute">almost everyone can perceive pitches</a> and rhythms.</p> <p>My research regarding children’s musicality suggests measures of singing skills are <a href="https://doi.org/10.1177/0022429416666054">normally distributed</a> in the population. That is, pitch ability follows a <a href="https://www.investopedia.com/terms/b/bell-curve.asp">bell curve</a>: Most people are average singers. Not many are way below average or excellent. </p> <p>My team’s most recent research suggests that this distribution is <a href="https://doi.org/10.1177/00224294211032160">true for rhythm</a> in addition to pitch. </p> <p>Not surprisingly, some musical skills are correlated.</p> <p>The more training you have on specific musical skills, the <a href="https://doi.org/10.1177/00224294211011962">better you’ll test on certain others</a>. This is probably because musical experience enhances other musical abilities.</p> <p>To sum it up, an emerging body of research indicates that practice doesn’t make perfect. But for most people, it helps a lot.</p> <h2>Lessons and practice are essential</h2> <p>What about people who say they they can’t keep a beat? It turns out that they almost always can track a steady beat to music. They just haven’t done it enough.</p> <p>Indeed, the last time I gave a nonbeliever our lab’s test for rhythm perception, she performed excellently. For that and for singing, some people just need <a href="https://www.nytimes.com/2020/01/21/magazine/how-to-sing-in-tune.html">a little help</a> to move past assumptions they lack talent: You can’t say you’re incapable of something if you haven’t spent time trying. </p> <p>Some researchers and <a href="https://strategiesforinfluence.com/malcolm-gladwell-10000-hour-rule/">journalists have promoted</a> the idea it takes <a href="https://doi.org/10.1037/0033-295X.100.3.363">10,000 hours of practice or training to master</a> a new skill. </p> <p>Innate ability puts people at different starting lines toward musical mastery. But once you’ve started to study an instrument or singing style, skill development depends on many other factors. Getting lessons, practicing often and being in a musical family may make those more likely.</p> <p>For example, Lizzo, a hip-hop superstar and classically trained flute player, had the luck to <a href="https://www.thefamouspeople.com/profiles/lizzo-44986.php">grow up in family of music lovers</a>. They all had their own taste in music. Her success is a microcosm of why a well-rounded musical education for young people matters.</p> <p>The singers in the choir I lead at Penn State have a range of experience, from a little to a lot. Yet soon after they join it, they develop the ability to <a href="https://doi.org/10.1177/87551233211040726">pick a good key and starting pitch</a> as they get to know their own voices. </p> <p>Practicing more doesn’t change your baseline potential, it just changes what you can presently do. That is, if you practice a specific song over and over again, eventually you’re going to get better at it.</p> <p>Jonathon Heyward, the Baltimore Symphony’s new conductor, who has <a href="https://www.nytimes.com/2022/07/21/arts/music/jonathon-heyward-baltimore-symphony-orchestra.html">no musicians in his family</a>, has worked really hard to excel. He started taking cello lessons at age 10 and hasn’t stopped since, playing and practicing and studying.</p> <h2>Privilege can play a role</h2> <p>Socioeconomic factors can also enter the equation. While conducting research, I’ve seen high-income college students from high-income families, with more years of musical experience, perform better than their classmates who have lower-income backgrounds and had fewer opportunities.</p> <p>Genes can give someone a head start. At the same time, having a quiet space where you can practice on an acoustic instrument or a digital workstation might make a more decisive difference for the musical prospects of most children. The same goes for having money for private lessons or access to free classes.</p> <p>Even so, many of the best musicians, including jazz greats <a href="https://www.louisarmstronghouse.org/biography/">Louis Armstrong</a> and <a href="https://www.pbs.org/wnet/americanmasters/billie-holiday-about-the-singer/68/">Billie Holiday</a>, grew up facing many hardships.</p> <p>With the right conditions for practice and gaining experience, who knows where the next Liza or Lizzo will come from.</p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/excelling-as-a-musician-takes-practice-and-requires-opportunities-not-just-lucky-genes-186693" target="_blank" rel="noopener">The Conversation</a>. </em></p>

Music

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Keeping to the beat controlled by 69 genes – not just our feet

<p class="spai-bg-prepared">Are you a dancing queen or do you have two left feet? Turns out that keeping to the beat is partly to do with our <a class="spai-bg-prepared" href="https://www.nature.com/articles/news.2007.359" target="_blank" rel="noreferrer noopener">genetics</a>.</p> <p class="spai-bg-prepared">An international team of researchers conducted a study on the genetic variation of 606,825 individuals, all of whom completed a musical ability questionnaire (including “Can you clap in time with a musical beat?”), with some also participating in beat synchronisation experiments including telling rhythms apart (Phenotype Experiment 1) and tapping in time with music (Phenotype Experiment 2).</p> <p class="spai-bg-prepared">Of the participants, 91.57% said yes to the question, “Can you clap in time with a musical beat?” Those who said yes also scored higher in the rhythm perception and tapping synchrony experiments.  </p> <p class="spai-bg-prepared">Looking at the genetic variation, 69 genes showed significant difference between the rhythmic and arhythmic participants, with <em class="spai-bg-prepared">VRK2 </em>being the most strongly associated. This gene has been linked previously to behavioural and psychiatric traits (including depression, schizophrenia and developmental delay), suggesting a biological link between beat synchronisation and neurodevelopment.</p> <div class="newsletter-box spai-bg-prepared"> <div id="wpcf7-f6-p195164-o1" class="wpcf7 spai-bg-prepared" dir="ltr" lang="en-US" role="form"> <form class="wpcf7-form mailchimp-ext-0.5.62 spai-bg-prepared init" action="/science/biology/keeping-the-beat-genetics/#wpcf7-f6-p195164-o1" method="post" novalidate="novalidate" data-status="init"> <p class="spai-bg-prepared" style="display: none !important;"><span class="wpcf7-form-control-wrap referer-page spai-bg-prepared"><input class="wpcf7-form-control wpcf7-text referer-page spai-bg-prepared" name="referer-page" type="hidden" value="https://cosmosmagazine.com/people/" data-value="https://cosmosmagazine.com/people/" aria-invalid="false" /></span></p> <p><!-- Chimpmail extension by Renzo Johnson --></form> </div> </div> <p class="spai-bg-prepared">Several physiology traits also seemed to be linked to beat synchronisation, including processing speed, grid strength, usual walking pace, and peak respiratory flow. These may be linked to the evolution of language and sociality through music in early humans.</p> <p class="spai-bg-prepared">For modern humans, our ability to keep the beat may help to predict developmental speech-language disorders, and serve as a mechanism for <a class="spai-bg-prepared" href="https://www.frontiersin.org/articles/10.3389/fnhum.2021.789467/full" target="_blank" rel="noreferrer noopener">rhythm-based rehabilitation</a>, including for <a class="spai-bg-prepared" href="https://cosmosmagazine.com/science/biology/bilingual-patients-recover-better-from-stroke/" target="_blank" rel="noreferrer noopener">stroke</a> and <a class="spai-bg-prepared" href="https://www.nature.com/articles/s41598-017-16232-5" target="_blank" rel="noreferrer noopener">Parkinson’s disease</a>.</p> <p class="spai-bg-prepared">This study has been <a class="spai-bg-prepared" href="https://doi.org/10.1038/s41562-022-01359-x" target="_blank" rel="noreferrer noopener">published</a> in <em class="spai-bg-prepared">Nature Human Behaviour</em>.</p> <figure class="wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio spai-bg-prepared"> <div class="wp-block-embed__wrapper spai-bg-prepared"> <div class="entry-content-asset spai-bg-prepared"> <div class="embed-wrapper spai-bg-prepared"> <div class="inner spai-bg-prepared"><iframe class="spai-bg-prepared" title="The Go-Go's - We Got The Beat (Official Music Video)" src="https://www.youtube.com/embed/f55KlPe81Yw?feature=oembed" width="500" height="281" frameborder="0" allowfullscreen="allowfullscreen"></iframe></div> </div> </div> </div> </figure> <p class="spai-bg-prepared">We got the beat… well maybe some of us!</p> <p><!-- Start of tracking content syndication. Please do not remove this section as it allows us to keep track of republished articles --></p> <p><img id="cosmos-post-tracker" class="spai-bg-prepared" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=195164&amp;title=Keeping+to+the+beat+controlled+by+69+genes+%E2%80%93+not+just+our+feet" width="1" height="1" /></p> <p><!-- End of tracking content syndication --></p> <div id="contributors"> <p><em><a href="https://cosmosmagazine.com/science/biology/keeping-the-beat-genetics/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/qamariya-nasrullah" target="_blank" rel="noopener">Qamariya Nasrullah</a>. Qamariya Nasrullah holds a PhD in evolutionary development from Monash University and an Honours degree in palaeontology from Flinders University.</em></p> <p><em>Image: Getty Images</em></p> </div>

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Willy Wonka fun facts

<p dir="ltr"><strong>*Willy Wonka Willy Wonka everybody give a cheer HOORAY*</strong></p> <p dir="ltr">Don’t pretend you did not sing that like the Oompa Loompa’s did because that is such a classic. </p> <p dir="ltr">Obviously the one with the late Gene Wilder, even though the one with Johnny Depp isn’t that bad either. </p> <p dir="ltr"><em>Willy Wonka and the Chocolate Factory</em> came out in 1971 and was based on the 1964 book <em><span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">Charlie and the Chocolate Factory </span></em><span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">by British author Roald Dahl</span><span style="font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;">.</span></p> <p dir="ltr">To this very day it remains a classic to grandparents, parents and even kids who grew up watching it. </p> <p dir="ltr">We all secretly wished we could visit Willy Wonka’s factory and consume all the chocolate possible…just like Augustus Gloop wanted to. </p> <p dir="ltr">But did you know that Willy Wonka’s factory wasn’t actually a factory? Yes, the movie has some delicious facts despite being released 51 years ago. </p> <ol> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Wonka’s limping entrance was Gene Wilder’s idea</strong></p> </li> </ol> <p dir="ltr">The first time everyone finally meets Willy Wonka is when he is limping. This idea came to Gene Wilder who suggested it would be perfect to keep the crowd on its toes.</p> <p dir="ltr">The director questioned why he would want to do that to which Gene responded: “Because from that time on, no one will know if I’m lying or telling the truth.”</p> <ol start="2"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Almost everything was edible</strong></p> </li> </ol> <p dir="ltr">Remember when Willy Wonka said “everything in this room is edible except for me”? Well they weren’t lying because everything in the factory was edible.</p> <p dir="ltr">Except for that floral cup he would drink from which was actually made from wax. Gene would bite into it and continue biting until the shot was perfect.</p> <ol start="3"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Chocolate river not actually made out of chocolate</strong></p> </li> </ol> <p dir="ltr">Would’ve been a dream come true had that river actually been made out of chocolate. It was however filled with brown-coloured water which eventually stunk up the place.</p> <p dir="ltr">In the remake, thick, fake chocolate was actually used. </p> <ol start="4"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Charlie and Wonka were close in real life</strong></p> </li> </ol> <p dir="ltr">Peter Ostrum, the actor who played Charlie, said Wilder “treated people with respect and dignity.” </p> <p dir="ltr">He said Wilder would always buy a chocolate bar after lunch and share it with him. </p> <ol start="5"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Not a factory</strong></p> </li> </ol> <p dir="ltr">The movie was filmed in Germany and Willy Wonka’s “factory” was in fact a power plant. </p> <p dir="ltr">The director chose that place on purpose so viewers would not immediately pick up where the story was set. </p> <ol start="6"> <li dir="ltr" aria-level="1"> <p dir="ltr" role="presentation"><strong>Roald Dahl HATED it</strong></p> </li> </ol> <p dir="ltr">Author Roald Dahl actually hated the film and refused to grant the film rights to a sequel. </p> <p dir="ltr">It was only 15 years after he died that a remake was approved.</p> <p dir="ltr"><em>Image: Getty</em></p>

Movies

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Feel connected to nature? It might be in your genes

<div><div class="copy"><p>Have you ever wondered why some people turn to wild places for solace, while others shudder at the thought of the untamed? Why some people’s idea of a great weekend away involves pitching a tent in a muddy field full of creepy crawlies, while others think camping is a lesser form of torture?</p><p>According to a <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001500" target="_blank" rel="noreferrer noopener">new study</a> published in <em>PLOS Biology</em>, the answer may be at least partially written into our genes.</p><p>In a collaboration with researchers from the National University of Singapore, the University of Queensland’s Professor Richard Fuller compared data from more than 1,000 sets of identical twins to find out how genetics may influence our relationship with nature.</p><p>“We compared twins who had been raised together with twins raised apart, in an attempt to demonstrate genetic heritability of two traits: how strongly they feel connected to nature, and the amount of time a person spends in nature,” Fuller says.</p><p>Their approach to the question, using identical twins, allowed them to tease apart the strength of genetic versus environmental influences.</p><p>Fuller says the team were “truly surprised” by their results, finding that nature-loving behaviours were heritable between 34 and 48% of the time.</p><p>“This means there may be innate genetic differences among people’s psychological connection with natural environments and how they experience them,” says Fuller.</p><p>“Our results help to explain why some people have a stronger desire than others to be in nature.”</p><p>A genetic component to the relationship between humans and the biosphere has long been speculated, often under the moniker of the “<a href="https://www.frontiersin.org/articles/10.3389/fpsyg.2021.700709/full" target="_blank" rel="noreferrer noopener">biophilia hypothesis</a>”, but this is the first time it has been convincingly demonstrated.</p><p>The current research builds genetic insight into our knowledge of nature-lust, which has previously been understood primarily through the lens of geographical circumstances. The new results suggest that while some of us may be genetically predisposed to connect with our wild side more than others, our circumstances still have a heady influence.</p><p>“Our results reinforced previous findings that a person’s environment is the predominant driver behind their enjoyment of nature,” Professor Fuller said.</p><p>“But the new information on the role of genetics in shaping our relationship with nature is a significant discovery.”</p><p>Lead author Dr Chia-chen Chang from the National University of Singapore believes the insight from this study may help to better inform efforts to bring people closer to nature, an issue that is becoming increasingly important as the impact of growing urbanisation on mental health becomes clearer.</p><p>“We know that more and more people today are living in urban environments, and this is usually associated with more mental health issues,” she says.</p><p>“This includes lower levels of subjective wellbeing, a higher risk of psychiatric disorders, or increased depression and anxiety.”</p><p>Chang says the process of connecting urban dwellers with the natural environment can prove challenging in our highly developed city-scapes, but that the benefits make the effort worthwhile.</p><p>“Spending a little time at home in the garden can be a great way to experience some nature, but this can’t always be achieved, especially for those in urban areas,” she says.</p><p>“Increasing accessibility to nature for urban residents through projects such as communal gardens will be hugely beneficial and will play an important part in improving people’s wellbeing overall.”</p><p>The results also add to a growing body of research that relies on insights from the study of twins, with the current study involving participants from <a href="https://twinsuk.ac.uk/" target="_blank" rel="noreferrer noopener">TwinsUK</a>: the United Kingdom’s largest adult twin registry and most clinically detailed twin study in the world.</p><p>TwinsUK, which has more than 14,000 registered twin participants, has been instrumental in progressing understanding of how genetic variation relates to human health and disease, with data underpinning 76 individual studies and over 800 publications to date.</p><p><em>Image credits: Getty Images</em></p><em><!-- Start of tracking content syndication. Please do not remove this section as it allows us to keep track of republished articles --> <img id="cosmos-post-tracker" style="height: 1px!important;width: 1px!important;border: 0!important" src="https://syndication.cosmosmagazine.com/?id=181148&amp;title=Feel+connected+to+nature%3F+It+might+be+in+your+genes" width="1" height="1" data-spai-target="src" data-spai-orig="" data-spai-exclude="nocdn" /> <!-- End of tracking content syndication --></em></div><div id="contributors"><p><em>This article was originally published on <a href="https://cosmosmagazine.com/health/body-and-mind/genetic-basis-for-biophilia/" target="_blank" rel="noopener">cosmosmagazine.com</a> and was written by Jamie Priest. </em></p></div></div>

Mind

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Feel connected to nature? It might be in your genes

<p>Have you ever wondered why some people turn to wild places for solace, while others shudder at the thought of the untamed? Why some people’s idea of a great weekend away involves pitching a tent in a muddy field full of creepy crawlies, while others think camping is a lesser form of torture?</p><div class="copy"><p>According to a <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001500" target="_blank" rel="noreferrer noopener">new study</a> published in <em>PLOS Biology</em>, the answer may be at least partially written into our genes.</p><p>In a collaboration with researchers from the National University of Singapore, the University of Queensland’s Professor Richard Fuller compared data from more than 1,000 sets of identical twins to find out how genetics may influence our relationship with nature.</p><p>“We compared twins who had been raised together with twins raised apart, in an attempt to demonstrate genetic heritability of two traits: how strongly they feel connected to nature, and the amount of time a person spends in nature,” Fuller says.</p><p>Their approach to the question, using identical twins, allowed them to tease apart the strength of genetic versus environmental influences.</p><p>Fuller says the team were “truly surprised” by their results, finding that nature-loving behaviours were heritable between 34 and 48% of the time.</p><p>“This means there may be innate genetic differences among people’s psychological connection with natural environments and how they experience them,” says Fuller.</p><p>“Our results help to explain why some people have a stronger desire than others to be in nature.”</p><p>A genetic component to the relationship between humans and the biosphere has long been speculated, often under the moniker of the “<a href="https://www.frontiersin.org/articles/10.3389/fpsyg.2021.700709/full" target="_blank" rel="noreferrer noopener">biophilia hypothesis</a>”, but this is the first time it has been convincingly demonstrated.</p><p>The current research builds genetic insight into our knowledge of nature-lust, which has previously been understood primarily through the lens of geographical circumstances. The new results suggest that while some of us may be genetically predisposed to connect with our wild side more than others, our circumstances still have a heady influence.</p><div class="newsletter-box"><div id="wpcf7-f6-p181148-o1" class="wpcf7" dir="ltr" lang="en-US" role="form"><p><span class="wpcf7-form-control-wrap referer-page"></span></p><!-- Chimpmail extension by Renzo Johnson --></div></div><p>“Our results reinforced previous findings that a person’s environment is the predominant driver behind their enjoyment of nature,” Professor Fuller said.</p><p>“But the new information on the role of genetics in shaping our relationship with nature is a significant discovery.”</p><p>Lead author Dr Chia-chen Chang from the National University of Singapore believes the insight from this study may help to better inform efforts to bring people closer to nature, an issue that is becoming increasingly important as the impact of growing urbanisation on mental health becomes clearer.</p><p>“We know that more and more people today are living in urban environments, and this is usually associated with more mental health issues,” she says.</p><p>“This includes lower levels of subjective wellbeing, a higher risk of psychiatric disorders, or increased depression and anxiety.”</p><p>Chang says the process of connecting urban dwellers with the natural environment can prove challenging in our highly developed city-scapes, but that the benefits make the effort worthwhile.</p><p>“Spending a little time at home in the garden can be a great way to experience some nature, but this can’t always be achieved, especially for those in urban areas,” she says.</p><p>“Increasing accessibility to nature for urban residents through projects such as communal gardens will be hugely beneficial and will play an important part in improving people’s wellbeing overall.”</p><p>The results also add to a growing body of research that relies on insights from the study of twins, with the current study involving participants from <a href="https://twinsuk.ac.uk/" target="_blank" rel="noreferrer noopener">TwinsUK</a>: the United Kingdom’s largest adult twin registry and most clinically detailed twin study in the world.</p><p>TwinsUK, which has more than 14,000 registered twin participants, has been instrumental in progressing understanding of how genetic variation relates to human health and disease, with data underpinning 76 individual studies and over 800 publications to date.</p><!-- Start of tracking content syndication. Please do not remove this section as it allows us to keep track of republished articles --> <img id="cosmos-post-tracker" style="height: 1px!important;width: 1px!important;border: 0!important" src="https://syndication.cosmosmagazine.com/?id=181148&amp;title=Feel+connected+to+nature%3F+It+might+be+in+your+genes" width="1" height="1" data-spai-target="src" data-spai-orig="" data-spai-exclude="nocdn" /> <!-- End of tracking content syndication --></div><div id="contributors"><p><em><a href="https://cosmosmagazine.com/health/body-and-mind/genetic-basis-for-biophilia/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/jamie-priest" target="_blank" rel="noopener">Jamie Priest</a>. Jamie Priest is a science journalist at Cosmos. She has a Bachelor of Science in Marine Biology from the University of Adelaide.</em></p><p><em>Image: Getty Images</em></p></div>

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Some endangered species can no longer survive in the wild. So should we alter their genes?

<p>Around the world, populations of many beloved species are declining at increasing rates. According to one <a href="https://www.theguardian.com/environment/2020/sep/30/world-plant-species-risk-extinction-fungi-earth">grim projection</a>, as many as 40% of the world’s species may be extinct by 2050. Alarmingly, many of these declines are caused by threats for which few solutions exist.</p> <p>Numerous species now depend on conservation breeding programs for their survival. But these programs typically do not encourage species to adapt and survive in the wild alongside intractable threats such as climate change and disease.</p> <p>This means some species can no longer exist in the wild, which causes major downstream effects on the ecosystem. Consider, for example, how a coral reef would struggle to function without corals.</p> <p>What if there was another way? My colleagues and I have developed an intervention method that aims to give endangered species the genetic features they need to survive in the wild.</p> <p><img src="https://images.theconversation.com/files/411140/original/file-20210714-13-1bf7ccv.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="bleached coral with fish" /> <span class="caption">Genetically altering coral may help them survive in a warmer world.</span> <span class="attribution"><span class="source">Rick Stuart-Smith</span></span></p> <h2>Bringing theory into practice</h2> <p>Over generations, natural selection enables species to adapt to threats. But in many instances today, the speed at which threats are developing is outpacing species’ ability to adapt.</p> <p>This problem is especially apparent in wildlife threatened by newly emerging infectious diseases such as chytridiomycosis in amphibians, and in climate-affected species such as corals.</p> <p>The toolkit my colleagues and I developed is called “targeted genetic intervention” or TGI. It works by increasing the occurrence or frequency of genetic features that impact an organism’s fitness in the presence of the threat. We outline the method in a recent <a href="https://www.sciencedirect.com/science/article/abs/pii/S0169534721003384">research paper</a>.</p> <p>The toolkit involves <a href="https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/artificial-selection">artificial selection</a> and <a href="https://www.frontiersin.org/articles/10.3389/fbioe.2019.00175/full">synthetic biology</a>. These tools are well established in agriculture and medicine but relatively untested as conservation tools. We explain them in more detail below.</p> <p>Many tools in our TGI toolkit have been discussed in theory in conservation literature in recent decades. But rapid developments in genome sequencing and synthetic biology mean some are now possible in practice.</p> <p>The developments have made it easier to understand the genetic basis of features which enable a species to adapt, and to manipulate them.</p> <p><img src="https://images.theconversation.com/files/442166/original/file-20220124-19-xc82dx.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="frog on wet rock" /> <span class="caption">Some animal species cannot adapt in time to survive threats such as disease.</span> <span class="attribution"><span class="source">Shutterstock</span></span></p> <h2>What is artificial selection?</h2> <p>Humans have long used artificial (or phenotypic) selection to promote desirable characteristics in animals and plants raised for companionship or food. This genetic alteration has led to organisms, such as domestic dogs and maize, that are dramatically different from their wild progenitors.</p> <p>Traditional artificial selection can lead to outcomes, such as high inbreeding rates, that affect the health and resilience of the organism and are undesirable for conservation. If you’ve ever owned a purebred dog, you might be aware of some of these genetic disorders.</p> <p>And when it comes to conservation, determining which individuals from a species are resistant to, say, a deadly pathogen would involve exposing the animal to the threat – clearly not in the interests of species preservation.</p> <p>Scientists in the livestock industry have developed a new approach to circumvent these problems. Called genomic selection, it combines data from laboratory work (such as a disease trial) with the genetic information of the animals to predict which individuals bear genetic features conducive to adaptation.</p> <p>These individuals are then chosen for breeding. Over subsequent generations, a population’s ability to survive alongside pervasive threats increases.</p> <p>Genomic selection has led to disease-resistant salmon and livestock that produce more milk and better tolerate heat. But it is yet to be tested in conservation.</p> <p><img src="https://images.theconversation.com/files/442161/original/file-20220124-27-11vyq0z.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="cows in green field" /> <span class="caption">Artificial selection has been used to develop traits that humans desire in livestock.</span> <span class="attribution"><span class="source">Shutterstock</span></span></p> <h2>What is synthetic biology?</h2> <p><a href="https://www.genome.gov/about-genomics/policy-issues/Synthetic-Biology">Synthetic biology</a> is a toolkit for promoting change in organisms. It includes methods such as transgenesis and gene editing, which can be used to introduce lost or novel genes or tweak specific genetic features.</p> <p>Recent synthetic biology tools such as <a href="https://medlineplus.gov/genetics/understanding/genomicresearch/genomeediting/">CRISPR-Cas9</a> have created a buzz in the medical world, and are also starting to gain the <a href="https://portals.iucn.org/library/node/48408">attention</a> of conservation biologists.</p> <p>Such tools can accurately tweak targeted genetic features in an individual organism – making it more able to adapt – while leaving the rest of the genome untouched. The genetic modifications are then passed on to subsequent generations.</p> <p>The method reduces the likelihood of unintended genetic changes that can occur with artificial selection.</p> <p>Synthetic biology methods are currently being trialled for conservation in multiple species around the world. These include the <a href="https://www.esf.edu/chestnut/resistance.htm">chestnut tree</a> and black-footed <a href="https://neo.life/2021/05/cloning-wildlife-and-editing-their-genes-to-protect-them-and-us/">ferrets</a> in the United States, and <a href="https://theconversation.com/gene-editing-is-revealing-how-corals-respond-to-warming-waters-it-could-transform-how-we-manage-our-reefs-143444">corals</a> in Australia.</p> <p>I am working with researchers at the University of Melbourne to develop TGI approaches in Australian frogs. We are trialling these approaches in the iconic southern corroboree frog, and plan to extend them to other species if they prove effective.</p> <p>Worldwide, the disease chytridiomycosis is devastating frog populations. Caused by the fungal pathogen <em>Batrachochytrium dendrobatidis</em>, it has led to the extinction of about <a href="https://www.nationalgeographic.com/animals/article/amphibian-apocalypse-frogs-salamanders-worst-chytrid-fungus">90 frog species</a> and declines in as many as 500 others.</p> <p>Many frog species now rely on conservation breeding for their continued survival. No effective solution for restoring chytrid-susceptible frogs to the wild exists, because the fungus cannot be eradicated.</p> <p><img src="https://images.theconversation.com/files/442155/original/file-20220124-23-cebr8a.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="gloved hand removed portion of DNA strand" /> <span class="caption">CRISPR technology could potentially be used to edit the genes of endangered species.</span> <span class="attribution"><span class="source">Shutterstock</span></span></p> <h2>Looking ahead</h2> <p>As with many conservation approaches, targeted genetic intervention is likely to involve trade-offs. For example, genetic features that make a species resistant to one disease may make it more susceptible to another.</p> <p>But the rapid rate of species declines means we should trial such potential solutions before it’s too late. The longer species are absent from an ecosystem, the greater the chance of irreversible environmental changes.</p> <p>Any genetic intervention of this type should involve all stakeholders, including Indigenous peoples and local communities. And caution should be taken to ensure species are fit for release and pose no risk to the environment.</p> <p>By bringing the concept of TGI to the attention of the public, government, and other scientists, we hope we will spur discussion and encourage research on its risks and benefits.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important; text-shadow: none !important;" src="https://counter.theconversation.com/content/175226/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><span><a href="https://theconversation.com/profiles/tiffany-kosch-1304685">Tiffany Kosch</a>, Research Fellow, <em><a href="https://theconversation.com/institutions/the-university-of-melbourne-722">The University of Melbourne</a></em></span></p> <p>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/some-endangered-species-can-no-longer-survive-in-the-wild-so-should-we-alter-their-genes-175226">original article</a>.</p> <p><em>Image: Melbourne Zoo</em></p>

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Breathtaking wilderness in the heart of coal country: after a 90-year campaign, Gardens of Stone is finally protected

<p>In the rocky upland wilderness of Wiradjuri Country two hours west of Sydney lies a new protected area with a <a href="https://www.nature.org.au/a_history_of_the_gardens_of_stone_campaign">nine-decade-long history</a> of dogged environmental activism: the Gardens of Stone.</p> <p>Last month, the New South Wales government <a href="https://www.parliament.nsw.gov.au/bill/files/3928/First%20Print.pdf">officially recognised</a> the Gardens of Stone as a State Conservation Area within the National Parks estate. <a href="https://www.nature.org.au/a_history_of_the_gardens_of_stone_campaign">First proposed in 1932</a> and with a small portion of the area designated as National Park in 1994, this decision will see more than 30,000 hectares finally protected.</p> <p>The government has also earmarked the region <a href="https://mattkean.com.au/news/media-release/gardens-stone-and-lost-city-adventures">for ecotourism</a>. With its epic gorges, the globally unique hanging swamps of Newnes Plateau, craggy cliff ravines and slot canyons, this 250-million-year-old geological landscape is a paradise for adventurers.</p> <p>But more than anything, the Gardens of Stone is, as stalwart campaigner Julie Favell puts it, a “<a href="https://www.theguardian.com/australia-news/2021/nov/13/storybook-of-nature-a-landmark-win-as-gardens-of-stone-in-nsws-blue-mountains-protected">storybook of nature</a>”. This is no simple story, but one of a <a href="https://www.sciencedirect.com/science/article/abs/pii/S0301421518302489">generational mining community</a> on the brink of social change and an often thankless, hard-won battle for ecological recognition in the heart of coal country.</p> <h2>Sandstone towers and rare wildlife</h2> <p>Towering sandstone and iron-banded <a href="https://www.youtube.com/watch?v=MNcceomLvs0&amp;ab_channel=IntotheWildFilms">pagoda formations</a> are what you’d most likely find on a Gardens of Stone postcard. These intricately weathered structures breach the eucalyptus canopy and cluster on a cliff, like a cross between the temples of Angkor Wat and a massive beehive complex.</p> <p><iframe width="440" height="260" src="https://www.youtube.com/embed/MNcceomLvs0?wmode=transparent&amp;start=0" frameborder="0" allowfullscreen=""></iframe> <span class="caption">The Lost City, Newnes Plateau, in Lithgow.</span></p> <p>For close and curious observers, there are also smaller, less dramatic icons. Rare wildflowers abound, including countless native orchids and the pagoda daisy, which grows only in rocky crags. In fact, the park is home to more than 40 threatened species, including the <a href="https://www.environment.nsw.gov.au/threatenedspeciesapp/profile.aspx?id=10841">regent honeyeater</a> and the <a href="https://www.environment.nsw.gov.au/threatenedspeciesapp/profile.aspx?id=10207">spotted-tail quoll</a>.</p> <p>A humble jewel of the Gardens of Stone is its endangered upland peat swamps. Resembling a meadow clearing, up close these swamps form watery spongescapes that function as both kitchen and nursery to hundreds of local species. Inhabitants include the endangered <a href="https://www.environment.nsw.gov.au/threatenedspeciesapp/profile.aspx?id=10322">Blue Mountains water-skink</a> and <a href="https://www.environment.nsw.gov.au/threatenedspeciesapp/profile.aspx?id=10600&amp;linkId=99343958">giant dragonfly</a>.</p> <p>These upland swamps on sandstone are found nowhere else in the world, and they play a critical role in <a href="https://www.tandfonline.com/doi/abs/10.1080/09640568.2019.1679100">regional water and climate resilience</a>, as they store carbon and mediate flooding and drought.</p> <p><a href="https://images.theconversation.com/files/434647/original/file-20211130-19-16t5mk1.jpeg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/434647/original/file-20211130-19-16t5mk1.jpeg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="" /></a> <span class="caption">Pagoda daisy, which grows nowhere else in Australia.</span> <span class="attribution"><span class="source">Julie Favell</span>, <span class="license">Author provided</span></span></p> <h2>A rocky battle</h2> <p>The environmental features of the Gardens of Stone are so intertwined with local, state and national conservation efforts that to tell the story of one is to tell the story of the other.</p> <p>Local environment groups have worked relentlessly to <a href="https://ro.uow.edu.au/scipapers/3063/">demonstrate the geological heritage</a> of the pagodas in the <a href="https://www.bluemountainsgazette.com.au/story/5067592/threat-to-gardens-of-stone-from-proposed-open-cut-mining/">face of open cut mining</a>. They have documented the impacts of mining on <a href="http://www.lithgowenvironment.org/pages/swamp%20watch.php">swamps and waterways</a>, tried to <a href="https://www.lithgowmercury.com.au/story/5268473/springvale-fined-for-damage-to-vegetation-in-endangered-swampland/">hold companies accountable</a> for their destruction, and recorded the presence of <a href="http://www.lithgowenvironment.org/pages/flora%20and%20fauna%201.php">many hundreds</a> of previously undocumented plant and animal species in an effort to have the area’s value formally recognised.</p> <p><a href="https://images.theconversation.com/files/434649/original/file-20211130-17-1wc5fr7.jpeg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/434649/original/file-20211130-17-1wc5fr7.jpeg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="" /></a> <span class="caption">Gooches Crater swamp, ringed by cliffs and pagodas.</span> <span class="attribution"><span class="source">Julie Favell</span>, <span class="license">Author provided</span></span></p> <p>This long campaign has also been the subject of <a href="https://www.abc.net.au/news/2017-08-02/springvale-mine-extension-blocked-in-court/8766742">legal battles</a> in the courts of NSW. The last two decades in particular have seen, for example, countless petitions, <a href="https://gggallery.com.au/anne-graham-2/">public events</a>, <a href="http://www.lithgowenvironment.org/pages/stream%20watch.php">environmental testing and monitoring projects</a>, and the task of sifting through technical mining documents with each new mining proposal.</p> <p>Two mines are currently in operation within the conservation area, with an extension to an <a href="https://www.centennialcoal.com.au/operations/angus-place/">existing site proposed</a>. The most significant impacts from mining in recent decades have been sandstone cracking, causing swamps to dry out and die, and disruptions to upland water flows and regional water quality.</p> <p><a href="https://images.theconversation.com/files/434651/original/file-20211130-15-13m3pgj.jpeg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/434651/original/file-20211130-15-13m3pgj.jpeg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="" /></a> <span class="caption">Lithgow Environment Group’s Chris Jonkers in a swamp damaged from nearby mining.</span> <span class="attribution"><span class="source">Julie Favell</span>, <span class="license">Author provided</span></span></p> <p>Conserving the Gardens of Stone has been an uphill battle in overcoming indifference and opposition.</p> <p>At the local level, environmental impacts from mining were <a href="https://www.lithgowmercury.com.au/story/2318819/mining-industry-again-a-target/">derided as inconsequential</a> in the face of mining employment, with campaigners bearing the brunt of <a href="https://www.theguardian.com/australia-news/2021/nov/13/storybook-of-nature-a-landmark-win-as-gardens-of-stone-in-nsws-blue-mountains-protected">distrust and hostility</a> from pro-coal locals towards their perceived interference.</p> <p>At the state level, hard-won environmental protections <a href="https://www.theguardian.com/australia-news/2017/oct/10/nsw-to-weaken-water-quality-test-for-extensions-to-mines">were overthrown in favour of mining approvals</a>. In 2017, the NSW government weakened laws to allow mining extensions that impacted Sydney’s drinking water quality, with <a href="https://www.environment.nsw.gov.au/topics/animals-and-plants/threatened-species/nsw-threatened-species-scientific-committee/determinations/final-determinations/2004-2007/alteration-of-habitat-following-subsidence-due-to-longwall-mining-key-threatening-process-listing">likely damage</a> to legally protected swamps within the Gardens of Stone not addressed.</p> <p>Due to existing mining developments, the extended Gardens of Stone isn’t officially designated as a National Park, but is instead a “<a href="https://www.nationalparks.nsw.gov.au/conservation-and-heritage/state-conservation-areas">conservation area</a>”. This means any new developments, such as extensions to mines, must use processes <a href="https://www.lithgowmercury.com.au/story/7368602/centennial-coal-propose-new-project-to-delight-of-environmentalists/">that support</a> conservation requirements.</p> <p><a href="https://images.theconversation.com/files/434655/original/file-20211130-21-1e6u2x3.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/434655/original/file-20211130-21-1e6u2x3.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="" /></a> <span class="caption">Spotted-tail quolls are one of the rare species living in the Gardens of Stone.</span> <span class="attribution"><span class="source">Shutterstock</span></span></p> <h2>Transitioning away from coal</h2> <p>Hopefully, encouraging responsible developments will avoid further <a href="https://www.abc.net.au/news/2021-04-30/gardens-of-stone-conservation-proposal/100103246">ecological damage</a> and help enable a smoother economic transition away from coal in the coming decades.</p> <p>Despite Australia’s <a href="https://www.washingtonpost.com/world/2021/11/11/coal-mining-australia-climate-cop26/">national climate strategy</a> remaining entrenched in coal, <a href="https://www.lithgowmercury.com.au/story/7291551/angus-place-in-doubt-after-parent-company-pivots-to-clean-energy-future/">local coal</a> prospects are winding down. This seems heralded by <a href="https://www.abc.net.au/news/2021-11-24/wallerawang-coal-demolition/100643694">last week’s demolition of Wallerawang Power Station</a> just outside the new conservation area.</p> <p>The new conservation area comes with a A$50 million investment, and will see hundreds of thousands of visitors flocking to explore a range of proposed new attractions. Chief among these will be the Lost City Adventure Experience, featuring Australia’s longest zipline and an elevated canyon walk, as well as a rock-climbing route and a six day wilderness track. These attractions are expected to create an extra 200 jobs.</p> <p>This new pivot towards ecotourism provides an example of a strategic and environmentally just transition pathway for the coal community in practice.</p> <p><a href="https://images.theconversation.com/files/434653/original/file-20211130-23-12arbsv.jpeg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/434653/original/file-20211130-23-12arbsv.jpeg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" alt="" /></a> <span class="caption">Pagodas at Newnes in the Gardens of Stone.</span> <span class="attribution"><span class="source">Julie Favell</span>, <span class="license">Author provided</span></span></p> <p>The Gardens of Stone victory may reflect a <a href="https://www.lithgowmercury.com.au/story/5577143/mundey-cfmeu-conservationists-talk-39000-hectare-state-reserve/">new dawn of negotiation</a> that could mark an end to the often antagonistic view of conservation as a threat to local livelihoods in this area.</p> <p>This victory and vision belongs squarely with its environmental campaigners, some of whom have <a href="https://www.nature.org.au/a_history_of_the_gardens_of_stone_campaign">given over 30 years of sustained and dedicated effort</a> to make it a reality.</p> <p>As the world’s attention is increasingly turned towards climate action, the success of this campaign may provide the surge of momentum we need for a more sustainable future.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important; text-shadow: none !important;" src="https://counter.theconversation.com/content/172503/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><span><a href="https://theconversation.com/profiles/hannah-della-bosca-416132">Hannah Della Bosca</a>, PhD Candidate and Research Assistant at Sydney Environment Institute, <em><a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a></em></span></p> <p>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/breathtaking-wilderness-in-the-heart-of-coal-country-after-a-90-year-campaign-gardens-of-stone-is-finally-protected-172503">original article</a>.</p>

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Indigenous knowledge and the persistence of the ‘wilderness’ myth

<div class="copy"> <p>According to the Oxford English dictionary, wilderness is defined as:</p> <blockquote class="wp-block-quote is-style-large"> <p>A wild or uncultivated region or tract of land, uninhabited, or inhabited only by wild animals; “a tract of solitude and savageness”.</p> </blockquote> <p>Aboriginal people in Australia view wilderness, or what is called “wild country”, as sick land that’s been neglected and not cared for. This is the opposite of the romantic understanding of wilderness as pristine and healthy – a view which underpins much non-Indigenous conservation effort.</p> <p>In a <a rel="noreferrer noopener" href="https://www.pnas.org/content/118/40/e2022218118" target="_blank">recent paper</a> for the Proceedings of the National Academy of Science, we demonstrate how many iconic “wilderness” landscapes – such as the Amazon, forests of Southeast Asia and the western deserts of Australia, are actually the product of long-term management and maintenance by Indigenous and local peoples.</p> <p>But this fact is often overlooked – a problem which lies at the heart of many of the world’s pressing environmental problems. Indigenous and local people are now excluded from many areas deemed “wilderness”, leading to the neglect or erasure of these lands.</p> <h2>The Anthropocene and Indigenous people</h2> <p>“Anthropocene” is the term scientists use to refer to the time period we live in today, marked by the significant and widespread impact of people on Earth’s systems. Recognition of this impact has sparked efforts to preserve and conserve what are believed to be “intact” and “natural” ecosystems.</p> <p>Yet, the Anthropocene concept has a problem: it is based on a European way of viewing the world. This worldview is blind to the ways Indigenous and local peoples modify and manage landscapes. It is based on the idea that all human activity in these conservation landscapes is negative.</p> <p>The truth is, most of Earth’s ecosystems have been influenced and shaped by Indigenous peoples <a rel="noreferrer noopener" href="https://www.pnas.org/content/118/17/e2023483118" target="_blank">for many thousands of years</a>.</p> <p>The failure of European-based “western” land management and conservation efforts to acknowledge the role of Indigenous and local peoples is reflected in recent scientific attempts to <a rel="noreferrer noopener" href="https://www.nature.com/articles/d41586-018-07183-6" target="_blank">define “wilderness”</a>. These attempts lay out a strict and narrow set of rules around what “human impact” is, and in so doing, act as gatekeepers for what it is to be human.</p> <p>The result is a scientific justification for conservation approaches that exclude all human involvement under the pretence of “wilderness protection”. The disregard for the deep human legacy in landscape preservation results in inappropriate management approaches.</p> <p>For example, fire suppression in landscapes that require burning can have catastrophic impacts, such as <a rel="noreferrer noopener" href="https://www.pnas.org/content/112/15/4531" target="_blank">biodiversity loss</a> and <a rel="noreferrer noopener" href="https://www.mdpi.com/2571-6255/4/3/61" target="_blank">catastrophic bushfires</a>.</p> <h2>Our case studies</h2> <p>In the Amazon, forest management by Indigenous and local peoples has promoted biodiversity and maintained forest structure for thousands of years. Areas of the Amazon considered “wilderness” contain domestic plant species, <a rel="noreferrer noopener" href="https://en.wikipedia.org/wiki/Terra_preta" target="_blank">anthropogenic soils</a> and significant earthworks (such as terraces and <a rel="noreferrer noopener" href="https://www.pnas.org/content/114/8/1868" target="_blank">geoglyphs</a>), revealing a deep human legacy in the Amazon landscape.</p> <p>Despite playing a key role in maintaining a healthy and diverse Amazon forest system, Indigenous and local peoples struggle constantly against wilderness-inspired conservation agendas that seek to deny them access to their homelands and livelihoods in the forest.</p> <p>Similarly, the forests of Southeast Asia and the Pacific are some of the most biodiverse regions on Earth. These forests have been managed for thousands of years using rotational agriculture based on small-scale forest clearing, burning and fallowing. Scientific attempts to define the last remaining “wild places” falsely map these areas as wilderness.</p> <p>Rather than being wild places, agriculture has actively promoted landscape biodiversity across the region, while supporting the lives and livelihoods of tens of millions of Indigenous and local peoples.</p> <p>In the central deserts of Australia, areas mapped today as “wilderness” are the ancestral homes of many Aboriginal peoples who have actively managed the land for tens of thousands of years.</p> <p>Removal of Traditional Owners in the 1960s had catastrophic effects on both the people and the land, such as uncontrolled wildfires and biodiversity loss. Unsurprisingly, a return of Aboriginal management to this region has seen a <a rel="noreferrer noopener" href="https://news.stanford.edu/news/2010/april/martu-burning-australia-042910.html" target="_blank">reduction in wildfires, a significant increase in biodiversity and healthier people</a>.</p> <p><em><strong>Read more: <a rel="noreferrer noopener" href="https://cosmosmagazine.com/earth/sustainability/although-we-didnt-produce-these-problems-we-suffer-them/" target="_blank">‘Although we didn’t produce these problems, we suffer them’</a></strong></em></p> <h2>A way forward</h2> <p>By framing landscapes created and managed by Indigenous and local peoples as wilderness, we are denying the land the care it requires. The effects of this neglect are evident in the catastrophic wildfires and environmental degradation occurring in Australia, northwest America and the Amazon – all lands invaded and colonised by Europeans.</p> <p>Climate change is now making these problems worse.</p> <p>Science alone has failed to solve these problems. Imposing land management approaches developed in Europe have failed. The idea of wilderness is destructive, and must be abandoned. We need new ways of engaging with the world around us if we’re to live sustainably on this planet.</p> <p>Indigenous and local peoples must be engaged in the full range of efforts that affect their lands. This includes developing and implementing environmental initiatives and policymaking, the production and execution of research, and environmental management.</p> <p>There are models that can be followed, such as developing Indigenous and community-conserved areas, Indigenous-protected and -conserved areas, or similar rights-based initiatives that merge the science and technology with the power of Indigenous and local knowledge.</p> <p>This is one way forward in effectively decolonising conservation and making the Earth healthy again.</p> <p><em><strong>Read more: <a rel="noreferrer noopener" href="https://cosmosmagazine.com/earth/sustainability/indigenous-stewardship-linked-to-biodiversity/" target="_blank">Indigenous stewardship linked to biodiversity</a></strong></em></p> <p><a rel="noreferrer noopener" href="https://theconversation.com/profiles/michael-shawn-fletcher-99786" target="_blank">Michael-Shawn Fletcher</a>, Associate Professor in Biogeography, <em><a rel="noreferrer noopener" href="https://theconversation.com/institutions/the-university-of-melbourne-722" target="_blank">The University of Melbourne</a></em>; <a rel="noopener" href="https://theconversation.com/profiles/lisa-palmer-1166017" target="_blank">Lisa Palmer</a>, Associate Professor, School of Geography, <em><a rel="noreferrer noopener" href="https://theconversation.com/institutions/the-university-of-melbourne-722" target="_blank">The University of Melbourne</a></em>; <a rel="noreferrer noopener" href="https://theconversation.com/profiles/rebecca-hamilton-1006537" target="_blank">Rebecca Hamilton</a>, Postdoctoral Fellow, <em><a rel="noreferrer noopener" href="https://theconversation.com/institutions/max-planck-institute-for-the-science-of-human-history-3416" target="_blank">Max Planck Institute for the Science of Human History</a></em>, and <a rel="noreferrer noopener" href="https://theconversation.com/profiles/wolfram-dressler-162824" target="_blank">Wolfram Dressler</a>, Senior Fellow, Development Geography, <em><a rel="noreferrer noopener" href="https://theconversation.com/institutions/the-university-of-melbourne-722" target="_blank">The University of Melbourne</a></em></p> <p>This article is republished from <a rel="noreferrer noopener" href="https://theconversation.com" target="_blank">The Conversation</a> under a Creative Commons license. Read the <a rel="noreferrer noopener" href="https://theconversation.com/indigenous-knowledge-and-the-persistence-of-the-wilderness-myth-165164" target="_blank">original article</a>.</p> <!-- Start of tracking content syndication. Please do not remove this section as it allows us to keep track of republished articles --> <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=167769&amp;title=Indigenous+knowledge+and+the+persistence+of+the+%E2%80%98wilderness%E2%80%99+myth" alt="" width="1" height="1" /></div>

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Willy Wonka star reveals Gene Wilder’s “favourite brat”

<p><span>A child star who had the opportunity to work alongside the infamous Gene Wilder has spoken out on the experience, 50 years since its first premier date.</span><br /><br /><em>Charlie and the Chocolate Factory </em><span>hit movie screens 50 years ago on June 30, 1971 and achieved rapid success almost overnight.</span><br /><br /><span>The film went on to become a phenomenon that was registered in the United States National Film Registry by the Library of Congress for being deemed “culturally, historically or aesthetically significant”.</span><br /><br /><span>The child actors Peter Ostrum, Julie Dawn Cole, Michael Bollner, Paris Themmen and Denise Nickerson – who played Charlie Bucket, Veruca Salt, Augustus Gloop, Mike Teavee and Violet Beauregarde – all came together for a virtual reunion in honour of the film’s anniversary.</span></p> <p><img style="width: 500px; height: 281.25px;" src="https://oversixtydev.blob.core.windows.net/media/7842239/willy-wonka.jpg" alt="" data-udi="umb://media/b9da36eca8c24fbeb170655d6cf92150" /></p> <p><em>Image: Yahoo</em><br /><br /><span>The actors all had the opportunity to co-star together, and even got to explore the imagined Wonka Chocolate Factory.</span><br /><br /><span>The cast recounted such fond memories of exploring the film sets in Bavarian Germany and working with Gene Wilder.</span><br /><br /><span>Themmen admitted that he was indeed a “notorious troublemaker on the set.”</span><br /><br /><span>So much so that even Wilder called him “a handful”.</span><br /><br /><span>“I can corroborate that,” the actor, who played the television-obsessed rascal Mike Teavee, admitted.</span><br /><br /><span>“I was younger than the others. I was 11, they were 13 and was naturally just sort of more high-spirited and rambunctious.”</span></p> <p><img style="width: 500px; height: 281.25px;" src="https://oversixtydev.blob.core.windows.net/media/7842237/willy-wonka-1.jpg" alt="" data-udi="umb://media/a8d501bcedd64f7b97dd573169a7717a" /></p> <p><em>Image: Yahoo</em><br /><br /><span>The now-62-year-old opened up about one brief moment he shared with Wilder, in 1976 during a fundraiser screening for the film <em>Silver Streak</em> at the Avon Theatre in Stamford, Connecticut.</span><br /><br /><span>“I sat at the back of the room and he gave his commentary and then I went up to the front of the room afterwards with my poster in hand,” Themmen relived with a smile.</span><br /><br /><span>“I said, ‘Hi, Gene, how you doing? I’m Paris Themmen, I was Mike Teavee in Willy Wonka.”</span><br /><br /><span>“And he said, ‘Oh you were a brat!’ And I flashed all the way back 50 years, or 40 years at that time, and said, ‘Well, I’m 50-something now and maybe not as much of a brat.’</span><br /><br /><span>And he signed my poster, ‘To my favourite brat.’”</span><br /><br /><span>Wilder died in 2016 at the age of 83 after a long vibrant career.</span><br /><br /><span>Cole, who played Veruca Salt, said: “I think people kind of want us to tell you that he was like Willy Wonka offset, but he wasn’t.</span><br /><br /><span>“He was such a lovely, kind man, very unassuming,” she said.</span><br /><br /><span>“He was just down to earth, not pretentious, he was just a wonderful person to be around and to work with,” said Ostrum, who played Charlie Bucket.</span></p>

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China's failed gene edited baby experiment proves we're not ready for human embryo modification

<p>More than a year ago, the world was shocked by Chinese biophysicist He Jiankui’s attempt to use CRISPR technology to modify human embryos and make them resistant to HIV, which led to the birth of twins Lulu and Nana.</p> <p>Now, crucial details have been revealed in a recent <a href="https://www.technologyreview.com/s/614764/chinas-crispr-babies-read-exclusive-excerpts-he-jiankui-paper/">release of excerpts</a> from the study, which have triggered a series of concerns about how Lulu and Nana’s genome was modified.</p> <p><strong>How CRISPR works</strong></p> <p>CRISPR is a technique that allows scientists to make precise edits to any DNA by altering its sequence.</p> <p>When using CRISPR, you may be trying to “knock out” a gene by rendering it inactive, or trying to achieve specific modifications, such as introducing or removing a desired piece of DNA.</p> <p>Gene editing with the CRISPR system relies on an association of two molecules. One is a protein, called Cas9, that is responsible for “cutting” the DNA. The other molecule is a short RNA (ribonucleic acid) molecule which works as a “guide” that brings Cas9 to the position where it is supposed to cut.</p> <p>The system also needs help from the cells being edited. DNA damage is frequent, so cells regularly have to repair the DNA lesions. The associated repair mechanisms are what introduce the deletions, insertions or modifications when performing gene editing.</p> <p><strong>How the genomes of Lulu and Nana were modified</strong></p> <p>He Jiankui and his colleagues were targeting a gene called CCR5, which is necessary for the HIV virus to enter into white blood cells (<a href="https://www.medicalnewstoday.com/articles/320987.php">lymphocytes</a>) and infect our body.</p> <p>One variant of CCR5, called CCR5 Δ32, is missing a particular string of 32 “letters” of DNA code. This variant naturally occurs in the human population, and results in a high level of resistance to the most common type of HIV virus.</p> <p>The team wanted to recreate this mutation using CRISPR on human embryos, in a bid to render them resistant to HIV infection. But this did not go as planned, and there are several ways they may have failed.</p> <p>First, despite claiming in the abstract of their unpublished article that they reproduced the human CCR5 mutation, in reality the team tried to modify CCR5 <em>close</em> to the Δ32 mutation.</p> <p>As a result, they generated different mutations, of which the effects are unknown. It may or may not confer HIV resistance, and may or may not have other consequences.</p> <p>Worryingly, they did not test any of this, and went ahead with implanting the embryos. This is unjustifiable.</p> <p><strong>The mosaic effect</strong></p> <p>A second source of errors could have been that the editing was not perfectly efficient. This means that not all cells in the embryos were necessarily edited.</p> <p>When an organism has a mixture of edited and unedited cells, it is called a “mosaic”. While the available data are still limited, it seems that both Lulu and Nana are mosaic.</p> <p>This makes it even less likely that the gene-edited babies would be resistant to HIV infection. The risk of mosaicism should have been another reason not to implant the embryos.</p> <p>Moreover, editing can have unintended impacts elsewhere in the genome.</p> <p>When designing a CRISPR experiment, you choose the “guide” RNA so that its sequence is unique to the gene you are targeting. However, “off-target” cuts can still happen elsewhere in the genome, at places that have a similar sequence.</p> <p>He Jiankui and his team tested cells from the edited embryos, and reported only one off-target modification. However, that testing required sampling the cells, which were therefore no longer part of the embryos - which continued developing.</p> <p>Thus, the remaining cells in the embryos had not been tested, and may have had different off-target modifications.</p> <p>This is not the team’s fault, as there will always be limitations in detecting off-target and mosaicism, and we can only get a partial picture.</p> <p>However, that partial picture should have made them pause.</p> <p><strong>A bad idea to begin</strong></p> <p>Above, we have described several risks associated with the modifications made on the embryos, which could be passed on to future generations.</p> <p>Embryo editing is only ethically justifiable in cases where the benefits clearly outweigh the risks.</p> <p>Technical issues aside, the researchers did not even address an unmet medical need.</p> <p>While the twins’ father was HIV-positive, there is already a well-established way to prevent an HIV-positive father from infecting embryos. This “<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779710/">sperm washing</a>” method was actually used by the team.</p> <p>The only benefit of the attempted gene modification, if proven, would have been a reduced risk of HIV infection for the twins later in life.</p> <p>But there are safer existing ways to control the risk of infection, such as condoms and mandatory testing of blood donations.</p> <p><strong>Implications for gene editing as a field</strong></p> <p>Gene editing has endless applications. It can be used to <a href="https://www.nature.com/articles/d41586-019-02770-7">make plants such as the Cavendish banana more resistant to devastating diseases</a>. It can play an important role in the adaptation to climate change.</p> <p>In health, we are already seeing <a href="https://www.npr.org/sections/health-shots/2019/11/19/780510277/gene-edited-supercells-make-progress-in-fight-against-sickle-cell-disease">promising results</a> with the editing of somatic cells (that is, non-heritable modifications of the patient’s own cells) in beta thalassemia and sickle cell disease.</p> <p>However, we are just not ready for human embryo editing. Our techniques are not mature enough, and no case has been made for a widespread need that other techniques, such as preimplantation genetic testing, could not address.</p> <p>There is also much work still needed on governance. There have been individual calls for a moratorium on embryo editing, and expert panels from the <a href="https://www.nature.com/articles/d41586-019-00942-z">World Health Organisation</a> to <a href="https://en.unesco.org/news/unesco-panel-experts-calls-ban-editing-human-dna-avoid-unethical-tampering-hereditary-traits">UNESCO</a>.</p> <p>Yet, no consensus has emerged.</p> <p>It is important these discussions move <a href="https://www.nature.com/articles/d41586-019-03525-0">in unison</a> to a second phase, where other stakeholders, such as patient groups, are more broadly consulted (and informed). Engagement with the public is also crucial.</p> <p><em>Correction: this article originally described RNA (ribonucleic acid) as a protein, rather than a molecule.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important; text-shadow: none !important;" src="https://counter.theconversation.com/content/128454/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: http://theconversation.com/republishing-guidelines --></em></p> <p><em><a href="https://theconversation.com/profiles/dimitri-perrin-392467">Dimitri Perrin</a>, Senior Lecturer, <a href="http://theconversation.com/institutions/queensland-university-of-technology-847">Queensland University of Technology</a> and <a href="https://theconversation.com/profiles/gaetan-burgio-202386">Gaetan Burgio</a>, Geneticist and Group Leader, The John Curtin School of Medical Research, <a href="http://theconversation.com/institutions/australian-national-university-877">Australian National University</a></em></p> <p><em>This article is republished from <a href="http://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/chinas-failed-gene-edited-baby-experiment-proves-were-not-ready-for-human-embryo-modification-128454">original article</a>.</em></p>

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